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We bring patients, carers and clinicians together to prioritise research questions for the benefit of health research funders.

About the JLA

We believe that patients, carers and clinicians should work together to agree which treatment uncertainties deserve attention and funding.

About PSPs

“This PSP has been a truly collaborative effort and ...

How do I set up a PSP?: When setting up your own Priority Setting Partnership (PSP), it is important that you read through the JLA Guidebook to understand the steps involved.

Templates and useful documents

A list of documents and templates useful when creating a PSP.

Using the JLA logo: Instructions for using the JLA logo on documents.

JLA Advisers

James Lind Alliance (JLA) Advisers are independent consultants who ...

History

The James Lind Alliance (JLA) was established in 2004 ...

What people say

As well as getting more research funded in a health area, PSPs have other benefits

The PSPs

Find out about all current and completed Priority Setting Partnerships, collaborations between clinicians and patients to identify research priorities.

Acne

Top 10 priorities: The top 10 priorities for the Acne PSP

Adult Social Work

More information about James Lind Alliance research priority setting work defining what the future research priorities are in social work for adults

Why did we do this
How did we do it
Who was involved: We had a Steering Group, which is the group ...
The survey
What social workers do
Top 10 Priorities: How is availability of funding impacting on (a) adult ...

Advanced Heart Failure

Top 10 priorities

Which treatments have the biggest impact on the quality ...

Priority 1 from the Advanced Heart Failure PSP: UNCERTAINTY: Which treatments have the biggest impact on the quality ...
Priority 3 from the Advanced Heart Failure PSP: UNCERTAINTY: What is the most empowering and effective education and ...
Priority 4 from the Advanced Heart Failure PSP: UNCERTAINTY: How can the work of heart failure charities be ...
Priority 5 from the Advanced Heart Failure PSP: UNCERTAINTY: Which approaches, in additional to standard therapies, are effective ...
Priority 6 from the Advanced Heart Failure PSP: UNCERTAINTY: How do we break down barriers for patients with ...
Priority 7 from the Advanced Heart Failure PSP: UNCERTAINTY: What are the benefits of asking a person with ...
Priority 8 from the Advanced Heart Failure PSP: UNCERTAINTY: What is the most effective way to use diuretics ...
Priority 9 from the Advanced Heart Failure PSP: UNCERTAINTY: How can advanced heart failure patients and professionals be ...
Priority 10 from the Advanced Heart Failure PSP: UNCERTAINTY: What support would be most effective for carers of ...
Priority 11 from the Advanced Heart Failure PSP: UNCERTAINTY: Which approaches are effective in reducing fatigue in people ...
Priority 12 from the Advanced Heart Failure PSP: UNCERTAINTY: Can the long-term care needs of people with advanced ...
Priority 14 from the Advanced Heart Failure PSP: UNCERTAINTY: Which approaches are effective in helping people with advanced ...
Priority 13 from the Advanced Heart Failure PSP: UNCERTAINTY:How can healthcare professionals manage the expectations of people ...
Priority 15 from the Advanced Heart Failure PSP: UNCERTAINTY: How do health professionals explain how advanced heart failure ...
Priority 16 from the Advanced Heart Failure PSP: UNCERTAINTY: What percentage of people with advanced heart failure have ...
Priority 17 from the Advanced Heart Failure PSP: UNCERTAINTY: How can we distinguish between co-morbidities (other chronic conditions) ...
Priority 18 from the Advanced Heart Failure PSP: UNCERTAINTY: How do people get support to continue as their ...
Priority 19 from the Advanced Heart Failure PSP: UNCERTAINTY: Which healthcare professional is most appropriate for people with ...
Priority 20 from the Advanced Heart Failure PSP: UNCERTAINTY: Do health professionals understand the life / activity / ...
Priority 21 from the Advanced Heart Failure PSP: UNCERTAINTY: Is there an ‘App’ to help people manage advanced ...
Priority 22 from the Advanced Heart Failure PSP: UNCERTAINTY: How do health professionals best manage chronic kidney disease ...
Priority 23 from the Advanced Heart Failure PSP: UNCERTAINTY: How do health professionals respond when people with advanced ...
Priority 24 from the Advanced Heart Failure PSP: UNCERTAINTY: What is the optimum time to discuss deactivation of ...
Priority 25 from the Advanced Heart Failure PSP: UNCERTAINTY: What helps with symptoms from peripheral oedema experienced by ...
Priority 2 from the Advanced Heart Failure PSP: UNCERTAINTY: What amount and type of exercise is safe and ...

Alcohol-related Liver Disease

Information about James Lind Alliance research priority setting work defining what the future research priorities are in alcohol-related liver disease

Top 10 priorities

The priority areas for future research around alcohol-related liver disease, agreed in September 2016

Priority 1 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What are the most effective ways to help people ...
Priority 2 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What are the most effective ways of delivering healthcare ...
Priority 3 from the Alcohol-related Liver Disease PSP
Priority 4 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What is the patient's experience of alcohol-related liver disease? (JLA PSP ...
Priority 5 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: Do attitudes to perceived 'self-induced illness' amongst healthcare ...
Priority 6 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What are the most effective strategies to reduce ...
Priority 7 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: Does the stigma associated with alcohol misuse affect ...
Priority 8 from the Alcohol-related Liver Disease PSP
Priority 9 from the Alcohol-related Liver Disease PSP
Priority 10 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What models of involvement of palliative care services ...
Priority 11 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: Are there any early signs of alcohol-related liver ...
Priority 12 from the Alcohol-related Liver Disease PSP
Priority 13 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What effect would greater alcohol-related liver disease education/training ...
Priority 14 from the Alcohol-related Liver Disease PSP
Priority 15 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What dietary recommendations or supplements (including herbal and ...
Priority 16 from the Alcohol-related Liver Disease PSP
Priority 17 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What are the most effective messages and how ...
Priority 18 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: Are there any effective treatments for alcohol-related liver ...
Priority 19 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What are the obstacles for individuals to modification ...
Priority 20 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What lifestyle interventions improve outcomes in alcohol-related liver ...
Priority 21 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What level and pattern of drinking behaviour affects the ...
Priority 22 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: To what degree is established liver disease reversible? ...
Priority 23 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What are the most effective interventions delivered in ...
Priority 24 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: What interventions improve survival in severe alcohol-related hepatitis? (JLA PSP ...
Priority 25 from the Alcohol-related Liver Disease PSP: UNCERTAINTY: Is there a difference between the outcome of alcohol-related ...

About the PSP

More information about the JLA Alcohol-related Liver Disease Priority Setting Partnership

Who was involved

Information about the Steering Group responsible for coordinating and organising the Alcohol-related Liver disease PSP.

Partners and support

How the James Lind Alliance partner organisations played a vital role in the priority setting process.

Anaesthesia and perioperative care

Top 10 priorities: (in no order of priority) What can we do to stop ...

Anaesthesia (Canada)

Top 10 Priorities

Which factors before, during, and after receiving anesthesia for ...

Priority 1 from the Anaesthesia (Canada) PSP: UNCERTAINTY: Which factors before, during, and after receiving anesthesia for ...
Priority 2 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What are the impacts of involving patients in shared ...
Priority 3 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What data should be collected from patients about ...
Priority 4 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How can errors and patient injuries in anesthesia care ...
Priority 5 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How can outcomes in frail and/or elderly patients be ...
Priority 6 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What is the impact of reducing opioids (a type ...
Priority 7 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What preparation, treatment, or assessment before receiving anesthesia ...
Priority 8 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How can patients’ feedback about their experiences before, during ...
Priority 9 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How can anesthesiologists improve pain control after surgery? (JLA PSP ...
Priority 10 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What are the common long-term side effects of ...
Priority 11 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What are the impacts of cannabis on anesthesia care ...
Priority 12 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How can anesthesiologists better use current (or create new) ...
Priority 13 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What choices in anesthesia care can improve patient outcomes, ...
Priority 14 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How well are patients supported after they are discharged ...
Priority 15 from the Anaesthesia (Canada) PSP: UNCERTAINTY: Are there specific surgeries for which regional anesthesia blocks ...
Priority 16 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How can health in frail and/or elderly patients be ...
Priority 17 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What are the impacts of anesthesia team communication on ...
Priority 18 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What is the evidence for better patient outcomes for ...
Priority 19 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What is the relationship between anesthetic drugs and post-operative ...
Priority 20 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What strategies can help reduce delirium after receiving anesthesia ...
Priority 21 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What is the evidence for eating and drinking before ...
Priority 22 from the Anaesthesia (Canada) PSP: UNCERTAINTY: How does having the same anesthesiologist and care team ...
Priority 23 from the Anaesthesia (Canada) PSP: UNCERTAINTY: What anesthesiologist factors impact patient outcomes? (JLA PSP Priority 23) Overall ...
Priority 24 from the Anaesthesia (Canada) PSP: UNCERTAINTY: Does the type or size of hospital impact the ...

Asthma

Top 10 priorities

The top 10 priorities of the Asthma PSP

Priority 1 from the Asthma PSP: UNCERTAINTY: a) What are the adverse effects associated with long ...
Priority 2 from the Asthma PSP: UNCERTAINTY: What is the most effective way of managing ...
Priority 3 from the Asthma PSP: UNCERTAINTY: What are the key components of successful "Self ...
Priority 4 from the Asthma PSP: UNCERTAINTY: What is the most effective strategy to educate ...
Priority 5 from the Asthma PSP: UNCERTAINTY: What is the most effective way of managing ...
Priority 6 from the Asthma PSP: UNCERTAINTY: What is the role of complementary therapies in ...
Priority 7 from the Asthma PSP: UNCERTAINTY: What are the benefits of breathing exercises as ...
Priority 8 from the Asthma PSP: UNCERTAINTY: What type of patient (children and adults) and ...
Priority 9 from the Asthma PSP: UNCERTAINTY: What is the most effective way to manage ...
Priority 10 from the Asthma PSP: UNCERTAINTY: Psychological interventions for adults with asthma? (JLA PSP Priority ...

Autism

Top 10 priorities

Bipolar

Bleeding Disorders

More information about work to set research priorities in bleeding disorders, with the James Lind Alliance

Top 10 priorities

What is the role and cost effectiveness of blood ...

Priority 1 from the Bleeding Disorder PSP: UNCERTAINTY: What is the role and cost effectiveness of blood ...
Priority 2 from the Bleeding Disorder PSP: UNCERTAINTY: How can we balance the risk and benefit of ...
Priority 3 from the Bleeding Disorder PSP: UNCERTAINTY: What is the best haematological approach to management of ...
Priority 4 from the Bleeding Disorder PSP: UNCERTAINTY: How should heavy periods be managed in women ...
Priority 5 from the Bleeding Disorder PSP: UNCERTAINTY: What is the relationship between immune thrombocytopenic purpura (ITP) ...
Priority 6 from the Bleeding Disorder PSP: UNCERTAINTY: What are the most effective treatments for acute ...
Priority 7 from the Bleeding Disorder PSP: UNCERTAINTY: What are the benefits of psychological and psychosocial strategies ...
Priority 8 from the Bleeding Disorder PSP: UNCERTAINTY: What are the genetic and environmental factors that predispose ...
Priority 9 from the Bleeding Disorder PSP: UNCERTAINTY: What is the best way to prevent or treat ...
Priority 10 from the Bleeding Disorder PSP: UNCERTAINTY: In people with haemophilia, what is the best way ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: Can a home testing device to record low platelets ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What is the role of exercise for both prevention ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What is the impact of the gut microbiome on ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What activities are NOT safe to do with any ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: In people with haemophilia, what are the most effective ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What causes the onset of immune thrombocytopenic purpura (ITP))? Overall ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: Is there an effective substitute for steroids in the ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: When is treatment for immune thrombocytopenic purpura (ITP) required? Overall ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What causes exacerbations of immune thrombocytopenic purpura (ITP)? Overall ranking This ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What is the psychological impact and burden of being ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: How can immediate (at the bedside/in the clinic) ultrasound ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: For people with haemophilia, can giving factor via a ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: Are there factors other than “the number of joint ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: Can haemorrhage after delivery, and its recurrence in subsequent ...
Priority from the Bleeding Disorder PSP: UNCERTAINTY: What overall (total) level of coagulation activity do you ...

Blood transfusion and blood donation

Top 10 priorities

What would encourage more people (especially black and ethnic ...

Priority 1 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What would encourage more people (especially black and ethnic ...
Priority 2 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can health professionals be discouraged from using ...
Priority 3 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can the wastage of donor blood be ...
Priority 4 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What is the optimal type and combination of ...
Priority 5 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can patients, relatives and carers be empowered ...
Priority 6 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can patients with anaemia be identified and ...
Priority 7 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What are the best drug alternatives to blood ...
Priority 8 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can the blood transfusion process be delivered ...
Priority 9 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What medical conditions make it unsafe for a ...
Priority 10 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What are the most effective ways to educate ...
Priority 11 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What is the psychological impact of blood transfusion ...
Priority 12 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can donation sessions be organised to make ...
Priority 13 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: Which patients groups would benefit most from artificial ...
Priority 14 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: Are drugs* a cost effective alternative to blood ...
Priority 15 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can any negative long term effects of ...
Priority 16 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What characteristics identify patients who would benefit from ...
Priority 17 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: Does the use of oral or intravenous iron ...
Priority 18 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What is the best administrative process for hospital ...
Priority 19 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: At what haemoglobin level [blood count] should a ...
Priority 20 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: Do patients and their relatives and/or carers receive ...
Priority 21 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What is the impact of iron deficiency on ...
Priority 22 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: What is the optimal blood transfusion dose [number ...
Priority 23 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How cost effective is cell salvage for the ...
Priority 24 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: At what haemoglobin level [blood count] should a ...
Priority 25 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How can the immediate side effects of receiving ...
Priority 26 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: At what haemoglobin level [blood count] should a ...
Priority 27 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: If the blood taken from a donor shows ...
Priority 28 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: How should patients who refuse blood transfusion be ...
Priority 29 from the Blood Transfusion and Blood Donation PSP: UNCERTAINTY: Why aren't previous recipients of a blood product ...

Broken bones in older people

The research priority setting work of the James Lind Alliance PSP.

Top 10 priorities: What is the best physiotherapy and/or occupational therapy regime ...

Cardiac Arrest (Canada)

Cavernoma

Top 10 priorities: The top 10 priorities of the Cavernoma PSP

Cellulitis

Top 10 priorities: How can healthcare professionals be best supported to accurately ...

Childhood disability

Top 10 priorities: Does the timing and intensity of therapies (e.g. physical, ...

Childhood Neurological Conditions

Children's Cancer

Cleft Lip and Palate

Top 10 priorities: What types of psychological intervention (individual therapy, community or ...

Coeliac Disease

Explains the work of the James Lind Alliance Priority Setting Partnership in Coeliac Disease, which is setting future research priorities

Common Conditions Affecting the Hand and Wrist

Details of the research priority setting work between patients and health professionals around common conditions of the hand and wrist

Complex Fractures

Ear nose and throat - Aspects of balance

Top 10 priorities: What is the optimal process for GP education and ...

Contraception

Top 10 priorities

Which interventions (decision support aids, ease of access, motivational ...

Priority 1 from the Contraception PSP: UNCERTAINTY: Which interventions (decision support aids, ease of access ...
Priority 2 from the Contraception PSP: UNCERTAINTY: What is the risk of side effects (vaginal ...
Priority 3 from the Contraception PSP: UNCERTAINTY: What are the long-term effects of using contraception ...
Priority 4 from the Contraception PSP: UNCERTAINTY: What models of care increase access and support ...
Priority 5 from the Contraception PSP: UNCERTAINTY: Which interventions are safe and effective for women ...
Priority 6 from the Contraception PSP: UNCERTAINTY: Does pharmacy provision of contraceptive services increase uptake ...
Priority 7 from the Contraception PSP: UNCERTAINTY: What are the risks or benefits to using ...
Priority 8 from the Contraception PSP: UNCERTAINTY: What factors (advice from friends, family, professionals, beliefs, ...
Priority 9 from the Contraception PSP: UNCERTAINTY: Are there tests or factors such as age ...
Priority 10 from the Contraception PSP: UNCERTAINTY: Are there effective new methods of contraception available ...
Priority 11 from the Contraception PSP: UNCERTAINTY: What are the most effective methods of promoting ...
Priority 12 from the Contraception PSP: UNCERTAINTY: What are the benefits and risks of using ...
Priority 13 from the Contraception PSP: UNCERTAINTY: If the progestogen-only pill was available over the ...
Priority 14 from the Contraception PSP: UNCERTAINTY: What is the risk of stroke for women ...
Priority 15 from the Contraception PSP: UNCERTAINTY: Are there health risks for women who take ...
Priority 16 from the Contraception PSP: UNCERTAINTY: Do progestogens used alone or in combined hormonal ...
Priority 17 from the Contraception PSP: UNCERTAINTY: Are there factors (ethnicity, past experience) that can ...
Priority 18 from the Contraception PSP: UNCERTAINTY: Does providing women who are pregnant with information ...
Priority 19 from the Contraception PSP: UNCERTAINTY: Do models of care (video information, telephone assessments, ...
Priority 20 from the Contraception PSP: UNCERTAINTY: How effective are 'natural family planning methods' (monitoring ...
Priority 21 from the Contraception PSP: UNCERTAINTY: Are intrauterine contraceptives (IUC) affected if not correctly ...
Priority 22 from the Contraception PSP: UNCERTAINTY: What are the health risks (osteoporosis, bone fracture) ...
Priority 23 from the Contraception PSP: UNCERTAINTY: Does ovulation, menstrual cycles and fertility return to ...
Priority 24 from the Contraception PSP: UNCERTAINTY: How frequently do women stop using the implant ...
Priority 25 from the Contraception PSP: UNCERTAINTY: How common is it for side effects (mood/weight ...
Priority 26 from the Contraception PSP: UNCERTAINTY: What methods of pain relief are effective during ...
Priority 27 from the Contraception PSP: UNCERTAINTY: Why aren't there progestogen only transdermal patches, gels, ...
Priority 28 from the Contraception PSP: UNCERTAINTY: Why don't more young women choose to use ...
Priority 29 from the Contraception PSP: UNCERTAINTY: What risk factors are there for deep insertion ...

Cystic Fibrosis

Top 10 priorities: The Top 10 future research priorities in Cystic Fibrosis, agreed on 13th January 2017 by patients, carers and health professionals with experience of the condition

Degenerative Cervical Myelopathy

Dementia

Top 10 priorities: What are the most effective components of care that ...

Dementia (Canada)

Top 10 priorities: The priorities for research around Dementia in Canada

Depression

Top 10 priorities: What are the most effective ways to prevent occurrence ...

Detecting Cancer Early

Diabetes (type 1)

Top 10 priorities: Is it possible to constantly and accurately monitor blood ...

Diabetes (type 2)

Top 10 uncertainties: Can type 2 diabetes be cured or reversed, what ...

Dialysis (Canada)

Top 10 uncertainties

Dystrophic Epidermolysis Bullosa (Spain)

Top ten uncertainties: Which wound care method obtains better outcomes (improved healing, ...

Early hip and knee osteoarthritis

Eating Disorders (Canada)

The Canadian Eating Disorder Priority Setting Partnership (CEDPSP) was ...

Eating disorders (Netherlands)

Eczema

Top 10 priorities: Shared priorities (important to patients and health professionals) What is ...

Elbow Conditions

Electronic cigarettes

Top 10 priorities: What are the long term effects of vaping? Compared ...

Emergency medicine

Top 10 priorities: What is the best way to reduce the harms ...

Endometriosis

Epilepsy

A summary of work done to set research priorities in Epilepsy in 2009

Epilepsy (Canada)

COPD Flare-ups

Fibromyalgia (Canada)

Top 10 priorities

Foot and Ankle Surgery

Frailty (Canada)

More information about the work of this James Lind Alliance PSP in Canada

Top 10 priorities: The research priorities chosen by patients, carers and clinicians in Canada in 2017 around Frailty

Hair loss

Top 10 priorities: for Alopecia areata (includes totalis, universalis and barbae) What are ...

Healthcare associated infections

Top 10 priorities: How can infections be identified early? How can we change ...

Head and Neck Cancer (Alberta, Canada)

Head and Neck Cancer is the sixth most common ...

The Top 10 Priorities: What is the best overall treatment combination or regimen ...

Heart Surgery

Describes the work of the James Lind Alliance Priority Setting Partnership to set research priorities around adult heart surgery

Hidradenitis suppurativa

Top 10 priorities

Please click on each question for more detailed information: What ...

Priority 1 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What is the most effective and safe group of ...
Priority 2 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What is the best management of an acute Hidradenitis ...
Priority 3 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What is the impact of Hidradenitis Suppurativa and the ...
Priority 4 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective are biologics (etanercept, adalimumab, infliximab, ustekinumab) in ...
Priority 5 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Does early diagnosis and aggressive treatment influence the course ...
Priority 6 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What is the best surgical procedure to perform in ...
Priority 7 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Which factors are useful in determining the prognosis (disease ...
Priority 8 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What is the best method of wound care ...
Priority 9 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: To what extent is Hidradenitis Suppurativa caused by genetic ...
Priority 10 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What is the best management of pain associated with ...
Priority 11 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Is Hidradenitis Suppurativa an autoimmune disease? (JLA PSP Priority ...
Priority 12 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How do we improve awareness of Hidradenitis Suppurativa amongst ...
Priority 13 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective are oral treatments that affect the immune ...
Priority 14 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: When is the best time to consider surgery to ...
Priority 15 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective are topical antiseptics in treating Hidradenitis Suppurativa? ...
Priority 16 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective are retinoids i.e acitretin, isotretinoin in treating ...
Priority 17 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How much do hormonal factors (puberty, menstruation, polycystic ovary ...
Priority 18 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Which oral antibiotic regimen is the most effective in ...
Priority 19 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective and safe are short term or long ...
Priority 20 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective are hormone therapies, including spironolactone, for Hidradenitis ...
Priority 21 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Is there an effective method (lifestyle, medical or surgery) ...
Priority 22 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Does weight reduction improve symptoms in people with Hidradenitis ...
Priority 23 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: How effective is metformin in treating Hidradenitis Suppurativa? (JLA ...
Priority 24 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: What causes the itching that can be associated with ...
Priority 25 from the Hidradenitis Suppurativa PSP: UNCERTAINTY: Is surgery effective in treating Hidradenitis Suppurativa? (JLA PSP ...
Priority 26 from the Hidradenitis Suppurativa PSP: UNCERTAINTY:What is the best psychological support for people with ...
Priority 27 from the Hidradenitis Suppurativa PSP: UNCERTAINTY:Does smoking affect Hidradenitis Suppurativa? (JLA PSP Priority 27) Overall ...
Priority 28 from the Hidradenitis Suppurativa PSP: UNCERTAINTY:Does diet have any effect on the severity of ...
Priority 29 from the Hidradenitis Suppurativa PSP: UNCERTAINTY:Does stress trigger a flare of Hidradenitis Suppurativa? (JLA ...
Priority 30 from the Hidradenitis Suppurativa PSP: UNCERTAINTY:Are natural products or dietary supplements (e.g. turmeric, zinc, ...

Hip and knee replacement for osteoarthritis

Top 10 priorities

What are the most important patient and clinical outcomes ...

Priority 1 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What are the most important patient and clinical outcomes ...
Priority 2 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What is the optimal timing for hip and knee ...
Priority 3 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: In people with OA, what are their pre operative ...
Priority 4 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What (health service) pre-operative, intra-operative, and post-operative factors can ...
Priority 5 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What is the best pain control regime pre-operatively, peri-operatively, ...
Priority 6 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What are the best techniques to control longer term ...
Priority 7 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What are the long-term outcomes of non surgical treatments ...
Priority 8 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What is the most effective pre and post operative ...
Priority 9 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What is an ideal postoperative follow up period and ...
Priority 10 from the Hip and Knee Replacement for Osteoarthritis PSP: UNCERTAINTY: What is the best way to protect patients from ...

Hyperemesis Gravidarum

Top 10 Priorities: Can we find a cure? What novel or new ...

Hyperhidrosis

Top 10 priorities: Are there any safe and effective permanent solutions for ...

Hypertension (Canada)

Top 10 priorities: What healthy lifestyle habits or combination of habits can ...

Inflammatory bowel disease

Top 10 priorities: What is the optimal treatment strategy considering efficacy, safety ...

Intensive care

Top 10 priorities: The Intensive Care PSP identified these questions as the ...

Juvenile Idiopathic Arthritis (Netherlands)

Kidney cancer (Canada)

Top 10 priorities: What are the treatment options for patients with advanced ...

Kidney transplant

Top 10 priorities

(in no order of priority): What is the best way ...

Priority 1 from the Kidney Transplant PSP: UNCERTAINTY: In kidney transplant patients, what is the best ...
Priority 2 from the Kidney Transplant PSP: UNCERTAINTY: In kidney transplant patients, how can immunosuppression be ...
Priority 3 from the Kidney Transplant PSP: UNCERTAINTY: How can we prevent sensitisation in patients with ...
Priority 4 from the Kidney Transplant PSP: UNCERTAINTY: Can we improve monitoring of the level of ...
Priority 5 from the Kidney Transplant PSP: UNCERTAINTY: How can we improve transplant rates in highly ...
Priority 6 from the Kidney Transplant PSP: UNCERTAINTY: What are the long-term health risks to the ...
Priority 7 from the Kidney Transplant PSP: UNCERTAINTY: How can we encourage tolerance to the transplant to prevent ...
Priority 8 from the Kidney Transplant PSP: UNCERTAINTY: What is the best combination of immunosuppressive drugs following ...
Priority 9 from the Kidney Transplant PSP: UNCERTAINTY: What techniques to preserve, condition and transport the kidney ...
Priority 10 from the Kidney Transplant PSP: UNCERTAINTY: Can bioengineered organs be developed to be as safe ...
Priority 11 from the Kidney Transplant PSP: UNCERTAINTY: Which combinations of immunosuppressive drugs can minimise side effects ...
Priority 12 from the Kidney Transplant PSP: UNCERTAINTY: For which patients is transplantation not suitable (considering factors ...
Priority 13 from the Kidney Transplant PSP: UNCERTAINTY: How can we increase the number of potential living ...
Priority 14 from the Kidney Transplant PSP: UNCERTAINTY: What is the best method of sharing deceased donor ...
Priority 15 from the Kidney Transplant PSP: UNCERTAINTY: Does routine screening for and treatment of donor-specific antibodies ...
Priority 16 from the Kidney Transplant PSP: UNCERTAINTY: How can we ensure fair and equal access to ...
Priority 17 from the Kidney Transplant PSP: UNCERTAINTY: What is the best way of educating patients about ...
Priority 18 from the Kidney Transplant PSP: UNCERTAINTY: For blood group incompatible transplants, which treatments most effectively ...
Priority 19 from the Kidney Transplant PSP: UNCERTAINTY: Which treatments work best to prolong the life of ...
Priority 20 from the Kidney Transplant PSP: UNCERTAINTY: How can we match organs to recipients to ensure ...
Priority 21 from the Kidney Transplant PSP: UNCERTAINTY: How do we prevent the original cause of kidney ...
Priority 22 from the Kidney Transplant PSP: UNCERTAINTY: What tests are required to determine whether a transplant ...
Priority 23 from the Kidney Transplant PSP: UNCERTAINTY: What approaches improve outcomes in adolescent and young adult ...
Priority 24 from the Kidney Transplant PSP: UNCERTAINTY: Is there a reliable way for us to assess ...

Lichen Sclerosus

More about the research priority setting work started in 2017

Top 10 Priorities

Liver Glycogen Storage Disease (International)

More about the James Lind Alliance Priority Setting Partnership setting research priorities with patients, families and healthcare professionals

Lyme disease

Top 10 priorities: How effective are the current UK tests in detecting ...

Maternal and Newborn Health Uganda

Medically Not Yet Explained Symptoms

Mesothelioma

More information about the Mesothelioma Priority Setting Partnership

Top 10 priorities

The top ten priorities for the JLA Mesothelioma Priority Setting Partnership

Priority 1 from the Mesothelioma PSP: UNCERTAINTY: Does boosting the immune system (using new agents such ...
Priority 2 from the Mesothelioma PSP: UNCERTAINTY: Can individualised chemotherapy be given to mesothelioma patients based ...
Priority 3 from the Mesothelioma PSP: UNCERTAINTY: What is the best way to monitor patients with ...
Priority 4 from the Mesothelioma PSP: In mesothelioma patients, what is the best second line ...
Priority 5 from the Mesothelioma PSP: UNCERTAINTY: Which is the most effective current treatment for ascites ...
Priority 6 from the Mesothelioma PSP: UNCERTAINTY: What are the relative benefits of immediate standard chemotherapy ...
Priority 7 from the Mesothelioma PSP: UNCERTAINTY: For mesothelioma patients, what is the best follow-up strategy ...
Priority 8 from the Mesothelioma PSP: UNCERTAINTY: In mesothelioma, is there a role for intrapleural immunostimulants ...
Priority 9 from the Mesothelioma PSP: UNCERTAINTY: Does an annual chest x-ray and/or CT scan and ...
Priority 10 from the Mesothelioma PSP: UNCERTAINTY: What, if any, are the benefits of pleurectomy (pleurectomy/decortication) ...
Priority 11 from the Mesothelioma PSP: UNCERTAINTY: Can PET scans (which produce 3D images of the ...
Priority 12 from the Mesothelioma PSP: UNCERTAINTY: How can the levels of mesothelin (a protein present ...
Priority 13 from the Mesothelioma PSP: UNCERTAINTY: What is the best current treatment for breathlessness in ...
Priority 14 from the Mesothelioma PSP: UNCERTAINTY: Is giving a course of chemotherapy to mesothelioma patients ...
Priority 15 from the Mesothelioma PSP: UNCERTAINTY: What is the best current method of managing mesothelioma ...
Priority 16 from the Mesothelioma PSP: UNCERTAINTY: Should treatment for mesothelioma, if the patient has no ...
Priority 17 from the Mesothelioma PSP: UNCERTAINTY: Is giving a course of radiotherapy to mesothelioma patients ...
Priority 18 from the Mesothelioma PSP: UNCERTAINTY: Is giving a course of radiotherapy to mesothelioma patients ...
Priority 19 from the Mesothelioma PSP: UNCERTAINTY: Would early referral to palliative care be beneficial for ...
Priority 20 from the Mesothelioma PSP: UNCERTAINTY: What is the value of weekly telephone support for ...
Priority 21 from the Mesothelioma PSP: UNCERTAINTY: What is the current best method (e.g. contrast enhanced ...
Priority 22 from the Mesothelioma PSP: UNCERTAINTY: Can rehabilitation be used to improve long term chronic ...
Priority 23 from the Mesothelioma PSP: UNCERTAINTY: Is there an overall benefit for standard chemotherapy in ...
Priority 24 from the Mesothelioma PSP: UNCERTAINTY: Should radiotherapy be given to mesothelioma patients at the ...
Priority 25 from the Mesothelioma PSP: UNCERTAINTY: What, if any, are the benefits of palliative surgery ...
Priority 26 from the Mesothelioma PSP: UNCERTAINTY: Should interventions (e.g. cordotomy or radiotherapy) be used to ...
Priority 27 from the Mesothelioma PSP: UNCERTAINTY: What is the best current treatment for fatigue in ...
Priority 28 from the Mesothelioma PSP: UNCERTAINTY: What is the best way to monitor patients with ...
Priority 29 from the Mesothelioma PSP: UNCERTAINTY: In mesothelioma patients, what is the best current treatment ...
Priority 30 from the Mesothelioma PSP: UNCERTAINTY: What is the best treatment to alleviate mucus in ...

About the PSP

Further information about the Mesothelioma and the JLA Priority Setting Partnership

Who was involved

The steering group for the Mesothelioma Priority Setting Partnership process

Partners and support

How the James Lind Alliance partner organisations played a vital role in the priority setting process.

The survey

The results of the survey carried out by the Mesothelioma Priority Setting Partnership

The priority setting workshop

Feedback and information on the Mesothelioma Priority Setting Workshop

Mild to moderate hearing loss

Top 10 priorities

What adverse effects are associated with not treating mild ...

Priority 1 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: What adverse effects are associated with not treating ...
Priority 2 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Does the early fitting of hearing aids result ...
Priority 3 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Does the early fitting of hearing aids slow ...
Priority 4 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: What are the reasons for low hearing aid ...
Priority 5 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Can new technologies replace hearing aids for the ...
Priority 6 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Can stem cell therapy offer a cure for ...
Priority 7 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Does early identification, diagnosis and treatment of mild ...
Priority 8 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Could new developments to digital hearing aids offer ...
Priority 9 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: How realistic are hearing tests for assessing the ...
Priority 10 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Could the use of real-world sounds to help ...
Priority 11 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: How effective and/or cost-effective are hearing aids for ...
Priority 12 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Could routine follow-up appointments help adults with mild ...
Priority 13 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: What is the effect of the use or ...
Priority 14 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: Can speech in noise tests offer additional diagnostic ...
Priority 15 from the Mild to Moderate Hearing Loss PSP: UNCERTAINTY: How effective are hearing tests (as part of ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - a: UNCERTAINTY: How frequently should hearing assessments be conducted to ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - b: UNCERTAINTY: What are the alternative tests to pure tone ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - c: UNCERTAINTY: Which type(s) of hearing aids are the most ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - d: UNCERTAINTY: Why is speech through hearing aids not clear ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - e: UNCERTAINTY: Is there a causal relationship between mild to ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - f: UNCERTAINTY: How can hearing aids be better designed to ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - g: UNCERTAINTY: How effective is deaf awareness training in retail ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - h: UNCERTAINTY: At what volume is leisure noise exposure damaging ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - i: UNCERTAINTY: Can hearing aids be designed to suppress intrusive ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - j: UNCERTAINTY: How can hearing aid technology be improved to ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - k: UNCERTAINTY: Can lipreading classes aid employment and/or reduce unemployment ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - l: UNCERTAINTY: How can hearing aid ear moulds be better ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - m: UNCERTAINTY: Which symptoms should adults and GPs use as ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - n: UNCERTAINTY:How can hearing aids best be programmed for adults ...
Priorities 16-30 from the Mild to Moderate Hearing Loss PSP - p: UNCERTAINTY:Could volume controls be improved on digital hearing aids ...

Miscarriage

Top 10 priorities: The priorities for research in the area of miscarriage, identified by the James Lind Alliance priority setting partnership in 2016

Mitochondrial disease

Top 10 priorities

Could an understanding of the cellular and molecular processes ...

Priority 1 from the Mitochondrial Disease PSP: UNCERTAINTY: Could an understanding of the cellular and molecular ...
Priority 2 from the Mitochondrial Disease PSP: UNCERTAINTY: Can the damage to cells caused by mitchondrial disease ...
Priority 3 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the biological mechanisms that cause mitochondrial disease ...
Priority 4 from the Mitochondrial Disease PSP: UNCERTAINTY: What biomarkers (biological markers that can be measured e.g. ...
Priority 5 from the Mitochondrial Disease PSP: UNCERTAINTY: Could gene therapy help people with mitochondrial disease? ...
Priority 6 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the psychological impacts of mitochondrial disease? What ...
Priority 7 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the best ways to reduce the risk ...
Priority 8 from the Mitochondrial Disease PSP: UNCERTAINTY: What factors could trigger the start of mitochondrial ...
Priority 9 from the Mitochondrial Disease PSP: UNCERTAINTY: Why are people with the same genetic mutation affected ...
Priority 10 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the most effective ways to treat and ...
Priority 11 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the genetic mutations that cause mitochondrial disease ...
Priority 12 from the Mitochondrial Disease PSP: UNCERTAINTY: Could a specific diet and/or supplements benefit people with ...
Priority 13 from the Mitochondrial Disease PSP: UNCERTAINTY: What can prevent mitochondrial disease from getting worse over ...
Priority 14 from the Mitochondrial Disease PSP: UNCERTAINTY: How do the different genetic mutations cause the symptoms ...
Priority 15 from the Mitochondrial Disease PSP: UNCERTAINTY: Is there a way to predict who will become ...
Priority 16 from the Mitochondrial Disease PSP: UNCERTAINTY: What can prevent the start of mitochondrial disease ...
Priority 17 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the most effective ways to treat and ...
Priority 18 from the Mitochondrial Disease PSP: UNCERTAINTY: What aspects of their health should be monitored over ...
Priority 19 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the most effective ways to treat ...
Priority 20 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the most effective ways to treat and ...
Priority 21 from the Mitochondrial Disease PSP: UNCERTAINTY: What are the most effective ways to treat and ...
Priority 22 from the Mitochondrial Disease PSP: UNCERTAINTY: How does mitochondrial disease change over time as people ...
Priority 23 from the Mitochondrial Disease PSP: UNCERTAINTY: Does exercise benefit people with mitochondrial disease? If ...
Priority 24 from the Mitochondrial Disease PSP: UNCERTAINTY: What causes the genetic mutation in people with ...

Multiple Conditions in Later Life

Multiple sclerosis

Top 10 priorities

Which treatments are effective to slow, stop or reverse ...

Priority 1 from the Multiple Sclerosis PSP: UNCERTAINTY: Which treatments are effective to slow, stop or ...
Priority 2 from the Multiple Sclerosis PSP: UNCERTAINTY: How can multiple sclerosis be prevented? (JLA PSP Priority ...
Priority 3 from the Multiple Sclerosis PSP: UNCERTAINTY: Which treatments are effective for fatigue in people ...
Priority 4 from the Multiple Sclerosis PSP: UNCERTAINTY: How can people with multiple sclerosis be best ...
Priority 5 from the Multiple Sclerosis PSP: UNCERTAINTY: Does early treatment with aggressive disease modifying drugs ...
Priority 6 from the Multiple Sclerosis PSP: UNCERTAINTY: Is vitamin D supplementation an effective disease modifying ...
Priority 7 from the Multiple Sclerosis PSP: UNCERTAINTY: Which treatments are effective to improve mobility for ...
Priority 8 from the Multiple Sclerosis PSP: UNCERTAINTY: Which treatments are effective to improve cognition in ...
Priority 9 from the Multiple Sclerosis PSP: UNCERTAINTY: Which treatments are effective for pain in people ...
Priority 10 from the Multiple Sclerosis PSP: UNCERTAINTY: Is physiotherapy effective in reducing disability in people ...

Myeloma (Canada)

Neurodevelopmental Disorders Canada

Neuro-oncology

Top 10 priorities: Do lifestyle factors (e.g. sleep, stress, diet) influence tumour ...

The Top 10 Priorities: What is the best treatment for people with early ...

Nutritional Screening and Malnutrition

Top 10 Priorities: How can early intervention be initiated in vulnerable groups ...

Obstructive Sleep Apnea (Saskatchewan,Canada)

Occupational Therapy

Top 10 Priorities: How does occupational therapy make a difference and have ...

Oral and Dental Health

Work done to set future research priorities in Oral and Dental Health by the James Lind Alliance Priority Setting Partnership started in 2017.

Pancreatic Cancer (Germany)

Top 10 Priorities: How can the best treatment for each individual patient ...

Paediatric Hospital Care (Canada)

Paediatric Lower Limb Surgery

Paediatric Lower Limb Surgery PSP

Top 10 Priorities

What are the best ways to measure the outcome ...

Priority 1 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the best ways to measure the ...
Priority 2 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: Following orthopaedic surgery to the lower limbs, ...
Priority 3 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the short-term and long-term clinical and cost ...
Priority 4 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the short term and long term outcome ...
Priority 5 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the clinical and cost effectiveness of pre-operative ...
Priority 6 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the short-term and long-term clinical and cost ...
Priority 7 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: Can surveillance and non-surgical treatment (e.g. physiotherapy, botulinum toxin ...
Priority 8 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the best method of screening for Developmental ...
Priority 9 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the best strategies to optimise communication of ...
Priority 10 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the best management for hip displacement ...
Priority 11 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the most effective interventions (including type ...
Priority 12 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: Does vitamin D supplementation or other diet supplements increase ...
Priority 13 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the clinical and cost effectiveness of gait ...
Priority 14 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the indications and most effective treatment ...
Priority 15 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the optimal surgical treatment and timing of ...
Priority 16 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the optimal management for severe stable Slipped ...
Priority 17 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the best treatment for patello-femoral instability (an ...
Priority 18 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the indications for surgical treatment of flatfeet ...
Priority 19 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the outcome of hip replacement in ...
Priority 20 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: Which operation leads to best results in the ...
Priority 21 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the best way to treat idiopathic ...
Priority 22 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the long-term outcomes of treatment in ...
Priority 23 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What is the effect of surgeon and centre ...
Priority 24 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What degree of lower limb anatomical variation (eg. ...
Priority 25 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: What are the indications for metalwork removal in ...
Priority 26 from the Paediatric Lower Limb Surgery PSP: UNCERTAINTY: Why is there geographical variation in the management ...

Parkinsons

Top 10 priorities: What treatments are helpful for reducing balance problems and ...

Palliative and end of life care

Top 10 priorities

What are the best ways of providing palliative care ...

Priority 1 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways of providing palliative ...
Priority 2 from the Palliative and end of life care PSP: UNCERTAINTY: How can access to palliative care services be ...
Priority 3 from the Palliative and end of life care PSP: UNCERTAINTY: What are the benefits of Advance Care Planning ...
Priority 4 from the Palliative and end of life care PSP: UNCERTAINTY: What information and training do carers and families ...
Priority 5 from the Palliative and end of life care PSP: UNCERTAINTY: How can it be ensured that staff, including ...
Priority 6 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to determine a ...
Priority 7 from the Palliative and end of life care PSP: UNCERTAINTY: What are the core palliative care services that should ...
Priority 8 from the Palliative and end of life care PSP: UNCERTAINTY: What are the benefits, and best ways, of ...
Priority 9 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to make sure ...
Priority 10 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to assess and ...
Priority 11 from the Palliative and end of life care PSP: UNCERTAINTY: How can people who live alone and do not ...
Priority 12 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways for healthcare professionals ...
Priority 13 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to facilitate communication ...
Priority 14 from the Palliative and end of life care PSP: UNCERTAINTY: What is the best way to give palliative ...
Priority 15 from the Palliative and end of life care PSP: UNCERTAINTY: How can distress that is not related to ...
Priority 16 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best modes of palliative care in ...
Priority 17 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to diagnose and ...
Priority 18 from the Palliative and end of life care PSP: UNCERTAINTY: What are the benefits of, and best approaches ...
Priority 19 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to make sure ...
Priority 20 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to manage acute ...
Priority 21 from the Palliative and end of life care PSP: UNCERTAINTY: What are the signs that a person will ...
Priority 22 from the Palliative and end of life care PSP: UNCERTAINTY: Is there an appropriate time to withdraw artificial ...
Priority 23 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to recognise and ...
Priority 24 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best care packages for patients, ...
Priority 25 from the Palliative and end of life care PSP: UNCERTAINTY: Are outcomes (for example, symptom control and incidental ...
Priority 26 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to support children ...
Priority 27 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best treatments for nausea and ...
Priority 28 from the Palliative and end of life care PSP: UNCERTAINTY: What are the best ways to manage the ...

Patient safety in primary care

Pessaries for Pelvic Organ Prolapse

More information about the work of the James Lind Alliance PSP in identifying and prioritising unanswered research questions about the use of pessaries in pelvic organ prolapse

Top 10 priorities

How might a pessary affect sexual activity? Do pessaries have an ...

Priority 1 from the Pessary use for Prolapse PSP: UNCERTAINTY: How might a pessary affect sexual activity? (JLA PSP Priority ...
Priority 2 from the Pessary use for Prolapse PSP: UNCERTAINTY: Do pessaries have an effect on the psychological ...
Priority 3 from the Pessary use for Prolapse PSP: UNCERTAINTY: What is important for a pessary self-management programme? (JLA PSP ...
Priority 4 from the Pessary use for Prolapse PSP: UNCERTAINTY: What are the risks and complications of pessary ...
Priority 5 from the Pessary use for Prolapse PSP: UNCERTAINTY: Are pessaries effective as a long-term treatment for prolapse? ...
Priority 6 from the Pessary use for Prolapse PSP: UNCERTAINTY: What is the best way to assess what type ...
Priority 7 from the Pessary use for Prolapse PSP: UNCERTAINTY: What is the best way to minimise and treat ...
Priority 8 from the Pessary use for Prolapse PSP: UNCERTAINTY: Does pessary use in prolapse have a positive impact ...
Priority 9 from the Pessary use for Prolapse PSP: UNCERTAINTY: When should oestrogen cream be used with a pessary? ...
Priority 10 from the Pessary use for Prolapse PSP: UNCERTAINTY: What is the ideal training to be a ...
Priority 11 from the Pessary use for Prolapse PSP: UNCERTAINTY: What level of prolapse will improve with the ...
Priority 12 from the Pessary use for Prolapse PSP: UNCERTAINTY: When is a pessary the right treatment for prolapse? ...
Priority 13 from the Pessary use for Prolapse PSP: UNCERTAINTY: What is the role of physiotherapy as part of ...
Priority 14 from the Pessary use for Prolapse PSP: UNCERTAINTY: Are pessaries effective in the treatment of prolapse? (JLA PSP ...
Priority 15 from the Pessary use for Prolapse PSP: UNCERTAINTY: Do the risks and complications of pessaries increase with ...
Priority 16 from the Pessary use for Prolapse PSP: UNCERTAINTY: What differences does a pessary make when used to ...
Priority 17 from the Pessary use for Prolapse PSP: UNCERTAINTY: Which pessary should be used for which prolapse? (JLA PSP ...
Priority 18 from the Pessary use for Prolapse PSP: UNCERTAINTY: What should be considered when choosing which type of ...
Priority 19 from the Pessary use for Prolapse PSP: UNCERTAINTY: Should women using pessaries be offered supervised pelvic ...
Priority 20 from the Pessary use for Prolapse PSP: UNCERTAINTY: What things make a difference to help with ...
Priority 21 from the Pessary use for Prolapse PSP: UNCERTAINTY: Is a pessary as acceptable as surgery for the ...
Priority 22 from the Pessary use for Prolapse PSP: UNCERTAINTY: Should a young woman with a non-bothersome prolapse be ...
Priority 23 from the Pessary use for Prolapse PSP: UNCERTAINTY: How safe are pessaries? (JLA PSP Priority 23) Overall ranking 23 JLA question ...
Priority 24 from the Pessary use for Prolapse PSP: UNCERTAINTY: Can women be taught to manage their own pessary? (JLA PSP ...
Priority 25 from the Pessary use for Prolapse PSP: UNCERTAINTY: Does the use of a pessary during or after ...

Pressure ulcers

Top 10 priorities

How effective is repositioning in the prevention of pressure ...

Priority 1 from the Pressure Ulcer PSP: UNCERTAINTY: How effective is repositioning in the prevention of ...
Priority 2 from the Pressure Ulcer PSP: UNCERTAINTY: How effective at preventing pressure ulcers is involving ...
Priority 3 from the Pressure Ulcer PSP: UNCERTAINTY: Does the education of health and social care ...
Priority 4 from the Pressure Ulcer PSP: UNCERTAINTY: How effective are the different types of pressure ...
Priority 5 from the Pressure Ulcer PSP: UNCERTAINTY: What impact do different service models have on ...
Priority 6 from the Pressure Ulcer PSP: UNCERTAINTY: What are the best service models to ensure ...
Priority 7 from the Pressure Ulcer PSP: UNCERTAINTY: For wheelchair users sitting on a pressure ulcer, ...
Priority 8 from the Pressure Ulcer PSP: UNCERTAINTY: How effective are wound dressings in the promotion ...
Priority 9 from the Pressure Ulcer PSP: UNCERTAINTY: Does regular turning of patients in bed promote ...
Priority 10 from the Pressure Ulcer PSP: UNCERTAINTY: Does improving diet (eating) and hydration (drinking) promote ...
Priority 11 from the Pressure Ulcer PSP: UNCERTAINTY: How effective are surgical operations to close pressure ...
Priority 12 from the Pressure Ulcer PSP: UNCERTAINTY: How effective are topical skin care products and ...
Priority 13 from the Pressure Ulcer PSP: Note that Priorities 13-21 are numbered for identification purposes, but were not ranked by the PSP
Priority 14 from the Pressure Ulcer PSP: UNCERTAINTY: Does exercise coaching help in the prevention of ...
Priority 15 from the Pressure Ulcer PSP: UNCERTAINTY: Is using a pressure ulcer risk rating scale ...
Priority 16 from the Pressure Ulcer PSP: UNCERTAINTY: How effective are incontinence devices at preventing ulcers? (JLA ...
Priority 17 from the Pressure Ulcer PSP: UNCERTAINTY: How effective is non-surgical debridement in ulcer healing, ...
Priority 18 from the Pressure Ulcer PSP: UNCERTAINTY: In people with multiple sclerosis which analgesics are ...
Priority 19 from the Pressure Ulcer PSP: UNCERTAINTY: What is the value of topical agents in ...
Priority 20 from the Pressure Ulcer PSP: UNCERTAINTY: How effective is negative pressure wound therapy as ...
Priority 21 from the Pressure Ulcer PSP: UNCERTAINTY: For people at risk of pressure ulcers how ...

Preterm birth

Top 10 priorities: Which interventions are most effective to predict or prevent ...

Prostate cancer

Top 10 priorities: How can overtreatment for prostate cancer be prevented by ...

Psoriasis

Information about the research priority setting work around Psoriasis started in 2017 using James Lind Alliance methods

Top 10 priorities: Do lifestyle factors such as diet, dietary supplements, alcohol, ...

Psoriatic Arthritis

Quality Use of Medicines in People Living with Dementia

Rare Anaemias Inherited

Details about the work of the James Lind Alliance Priority Setting Partnership in identifying research uncertainties around Rare Anaemias

Top 10 Priorities: Would a national formal network of clinicians with expertise ...

Rare Musculoskeletal Diseases in Adulthood

A summary of priority setting work in this area using James Lind Alliance methods

Top 10 Priorities

What is considered a good outcome of treatment in ...

Priority 1 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What is considered a good outcome of treatment in ...
Priority 2 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What is the cause of pain in people with ...
Priority 3 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What is the psychological impact of having a ...
Priority 4 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What can be done to prevent rare metabolic bone ...
Priority 5 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What are the best ways to manage fatigue ...
Priority 6 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What are the best forms of surgery to ...
Priority 7 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What are the benefits and side effects of drug ...
Priority 8 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: How do rare metabolic bone disorders progress as people ...
Priority 9 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: How are other parts of the body affected by ...
Priority 10 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What are the best ways to prevent dental problems ...
Priority = 10 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: How and why do people with rare metabolic bone ...
Priority 12 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Are there more effective, long-term treatments for pain (including ...
Priority 13 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: How does menopause impact on women with rare metabolic ...
Priority 14 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: How does care and support for adults need ...
Priority 15 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Are people with rare metabolic bone disorders at risk ...
Priority 16 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Could a combination of self-management approaches reduce pain and ...
Priority 17 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What is the best way to link up and ...
Priority 18 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Which treatments are safer and more effective for people ...
Priority 19 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: What is the best form of exercise for people ...
Priority 20 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: How does drug treatment need to change as people ...
Priority 21 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Is stem cell therapy an effective treatment for people ...
Priority 22 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Why are some health professionals unaware of rare metabolic ...
Priority 23 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: If we have a better understanding of what causes ...
Priority 24 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Would specialist services result in better care for people ...
Priority 25 from the Rare Musculoskeletal Diseases in Adulthood PSP: UNCERTAINTY: Is life expectancy affected by rare metabolic bone disorders? ...

Retention in Randomised Trails

Describing the work of a priority setting partnership in identifying uncertainties around what we know about the best ways to encourage people to stay involved in clinical trails

Top 10 priorities: What motivates a participant’s decision to complete a clinical ...

Revision Knee Replacement

Top 10 Priorities

What are the causes of persistent pain following a ...

Priority 1 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the causes of persistent pain following a ...
Priority 2 from the Revision Knee Replacement PSP: UNCERTAINTY: What is the best way to diagnose and ...
Priority 3 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the most effective ways to organise health ...
Priority 4 from the Revision Knee Replacement PSP: UNCERTAINTY: What factors determine (predict) whether revision knee surgery ...
Priority 5 from the Revision Knee Replacement PSP: UNCERTAINTY: What can be done after and/or before revision knee ...
Priority 6 from the Revision Knee Replacement PSP: UNCERTAINTY: What is the psychological impact of a problematic knee ...
Priority 7 from the Revision Knee Replacement PSP: UNCERTAINTY: How should we measure the outcomes following revision knee ...
Priority 8 from the Revision Knee Replacement PSP: UNCERTAINTY: Is there a way to manage some types ...
Priority 9 from the Revision Knee Replacement PSP: UNCERTAINTY: What causes knee stiffness following knee replacement? How can ...
Priority 10 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the best forms of surgery to ...
Priority 11 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the best ways to investigate the causes ...
Priority 12 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the best treatments for pain in ...
Priority 13 from the Revision Knee Replacement PSP: UNCERTAINTY: What is the best way to treat a break ...
Priority 14 from the Revision Knee Replacement PSP: UNCERTAINTY: How long does a revision knee replacement last and ...
Priority 15 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the best ways to manage patients’ unmet ...
Priority 16 from the Revision Knee Replacement PSP: UNCERTAINTY: What factors increase the risks of infection and ...
Priority 17 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the long-term outcomes when a knee ...
Priority 18 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the best non-surgical treatments around the time ...
Priority 19 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the most effective forms of pain relief ...
Priority 20 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the long-term outcomes of revision knee surgery? ...
Priority 21 from the Revision Knee Replacement PSP: UNCERTAINTY: What are the best ways to investigate implant-related failure ...
Priority 22 from the Revision Knee Replacement PSP: UNCERTAINTY: If necessary following infection in a knee replacement, ...
Priority 23 from the Revision Knee Replacement PSP: UNCERTAINTY: What is the best way to restore lost bone ...

Safe Care for Adults with Complex Health Needs

More details about the James Lind Alliance Priority Setting Partnership in Patient Safety

Top 10 Priorities: When people with complex health needs require care from ...

Schizophrenia

Top 10 priorities: What is the best way to treat people with ...

Scoliosis

How the James Lind Alliance Priority Setting Partnership in Scoliosis will work and how you can find out more

Seniors' Health (Alberta, Canada)

Top 10 Priorities: What strategies best allow older adults to remain independent ...

Sexual Violence

Sight loss and vision

Top 10 priorities

The Sight Loss and Vision PSP set Top 10 priorities ...

Can a treatment to stop dry AMD progressing and/or ...

Priority 1 from the Sight Loss and Vision PSP Age Related: UNCERTAINTY: Can a treatment to stop dry age related ...
Priority 2 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: What is the cause of age related ...
Priority 3 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: How can age related macular degeneration (AMD) ...
Priority 4 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: Are there ways of restoring sight loss ...
Priority 5 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: Can the development of age related macular ...
Priority 6 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: What is the most effective way to ...
Priority 7 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: What factors influence the progression of age ...
Priority 8 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: Can a non-invasive therapy be developed for ...
Priority 9 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: Can dietary factors, nutritional supplements, complementary therapies ...
Priority 10 from the Sight Loss and Vision PSP Age Related Macular Degeneration: UNCERTAINTY: What are the best enablement strategies for ...

Cataract Top 10

How can cataracts be prevented from developing? Can the return ...

Priority 1 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: How can we prevent cataracts from developing? (JLA PSP ...
Priority 2 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: Can the return of cloudy or blurred vision ...
Priority 3 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: How can cataract progression be slowed down? (JLA ...
Priority 4 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: What alternatives to treat cataracts other than cataract ...
Priority 5 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: What is the cause of cataract? (JLA PSP Priority ...
Priority 6 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: How can cataract surgery outcome be improved? (JLA PSP ...
Priority 7 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: How safe and effective is laser assisted cataract ...
Priority 8 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: Should accommodative lenses be developed for cataract surgery? (JLA ...
Priority 9 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: What is the best measure of visual disability ...
Priority 10 from the Sight Loss and Vision PSP Cataract: UNCERTAINTY: Can retinal detachment be prevented after cataract surgery? (JLA ...

Childhood Onset Disorders Top 10

How can cerebral visual impairment be identified, prevented and ...

Priority 1 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: How can cerebral visual impairment be identified, prevented ...
Priority 2 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: How can we develop treatment for visual pathway ...
Priority 3 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: How do we improve screening and surveillance from ...
Priority 4 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: Can the treatment of amblyopia be improved to ...
Priority 5 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: How can cataract be prevented in children? (JLA PSP ...
Priority 6 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: What are the causes of coloboma and microphthalmia/anophthalmia ...
Priority 7 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: Can vision be corrected in later life for ...
Priority 8 Sight Loss and Vision PSP Childhood Disorders: UNCERTAINTY: How can retinoblastoma be identified, prevented and treated ...
Priority 9 Sight Loss and Vision PSP Childhood Disorder: UNCERTAINTY: Can better treatments for glaucoma in children be ...
Priority 10 Sight Loss and Vision PSP Childhood Disorder: UNCERTAINTY: Can a treatment be developed to improve vision ...

Corneal and External Eye Conditions Top 10

Can new therapies such as gene or stem cell ...

Glaucoma Top 10

What are the most effective treatments for glaucoma and ...

Inherited Retinal Disease

Can a treatment to slow down progression or reverse ...

Neuro-ophthalmology Top 10

What is the underlying cause of optic nerve damage ...

Ocular Cancer Top 10

What can be done to help ocular cancer sufferers? Can ...

Ocular Inflammatory Disease Top 10

What are the most effective treatments for ocular and ...

Priority 8 Sight Loss and Vision PSP Ocular Inflammatory Disease: UNCERTAINTY: What medications best prevent the development of eye ...

Refractive Error and Ocular Motility Top 10

What factors influence the development of refractive error (myopia, ...

Retinal Vascular Disease Top 10

What are the best methods to prevent retinopathy of ...

Vitreoretinal or Ocular Trauma Top 10

How can surgical techniques be improved to save sight ...

Spinal cord injury

Top 10 priorities: Does activity based rehabilitation, including functional electrical stimulation coupled ...

Stillbirth

Top 10 priorities

How can the structure and function of the placenta ...

Priority 1 from the Stillbirth PSP: UNCERTAINTY: How can the structure and function of the placenta ...
Priority 2 from the Stillbirth PSP: UNCERTAINTY: Does ultrasound assessment of fetal growth in the third ...
Priority 3 from the Stillbirth PSP: UNCERTAINTY: Do modifiable ‘lifestyle’ factors (e.g. diet, vitamin deficiency, sleep ...
Priority 4 from the Stillbirth PSP: UNCERTAINTY: Which investigations identify a fetus which is at risk ...
Priority 5 from the Stillbirth PSP: UNCERTAINTY: Can the wider use of existing tests and monitoring ...
Priority 6 from the Stillbirth PSP: UNCERTAINTY: What causes stillbirth in normally grown babies? (JLA PSP ...
Priority 7 from the Stillbirth PSP: UNCERTAINTY: What is the most appropriate bereavement and post natal ...
Priority 8 from the Stillbirth PSP: UNCERTAINTY: Which antenatal care interventions are associated with a reduction ...
Priority 9 from the Stillbirth PSP: UNCERTAINTY: Would more accessible evidence-based information on signs and symptoms ...
Priority 10 from the Stillbirth PSP: UNCERTAINTY: How can staff support women and their partners in ...
Priority 11 from the Stillbirth PSP: UNCERTAINTY: Why is the incidence of stillbirth in the UK ...

Stroke

Life after Stroke

Top 10 priorities: What are the best ways to improve cognition after ...

Surgery for common shoulder problems

Top 10 priorities: (in no order of priority): For the main shoulder conditions ...

Teenage and Young Adult Cancer

More information about identifying and setting research priorities in teenage and young adult cancer

The Top 10 Priorities

What psychological support package improves psychological well-being, social functioning ...

Priority 1 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What psychological support package improves psychological well-being, social functioning ...
Priority 2 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What interventions, including self-care, can reduce or reverse adverse ...
Priority 3 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the best strategies to improve access to ...
Priority 4 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What General Practitioner or young person strategies, such as ...
Priority 5 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the best ways of supporting a young ...
Priority 6 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the most effective strategies to ensure that ...
Priority 7 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What interventions are most effective in supporting young people ...
Priority 8 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: How can parents/carers/siblings/partners be best supported following the death ...
Priority 9 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What is the best method of follow-up and timing ...
Priority 10 from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What targeted treatments are effective and have fewer short ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the long term physical effects of a ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What factors affect the time to diagnosis and what ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What can young people do to help their recovery ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What causes problems with cognitive functioning (chemobrain), how long ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the best strategies for detecting and treating ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: For young people with incurable cancer, how should healthcare ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the long-term physical effects of stem cell ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: For young people with incurable cancer, how should parents/carers ...
Priority from the Teenage and Young Adult Cancer PSP: UNCERTAINTY: What are the support needs of the family following ...

Tinnitus

Top 10 priorities: (in no order of priority) What management strategies are more ...

Treatment of Pemphigus and Pemphigoid

Urinary incontinence

Top 10 priorities: What are the optimal pelvic floor muscle training protocols ...

Venous Thromboembolism (Canada)

Vitiligo

Top 10 priorities: How effective are systemic immunosuppressants in treating vitiligo? How much ...

Womb-cancer

Top 10 priorities

The top priorities for future research in the area of endometrial (womb) cancer, set in 2015 by patients, carers and health professionals

Priority 1 from the Womb Cancer psp: The top priority from the James Lind Alliance Womb Cancer research Priority Setting Partnership
Priority 2 from the Womb Cancer PSP: Priority 2 from the James Lind Alliance Womb Cancer Priority Setting Partnership
Priority 3 from the Womb Cancer PSP: Priority 3 from the James Lind Alliance Womb Cancer Priority Setting Partnership
Priority 4 from the Womb Cancer PSP: Priority 4 from the James Lind Alliance Womb Cancer PSP
Priority 5 from the Womb Cancer PSP: Priority 5 from the James Lind Alliance Womb Cancer PSP
Priority 6 from the Womb Cancer PSP: Priority 6 from the James Lind Alliance Womb Cancer PSP
Priority 7 from the Womb Cancer PSP: Priority 7 from the James Lind Alliance Womb Cancer PSP
Priority 8 from the Womb Cancer PSP: Priority 8 from the James Lind Alliance Womb Cancer PSP
Priority 9 from the Womb Cancer PSP: Priority 9 from the James Lind Alliance Womb Cancer PSP
Priority 10 from the Womb Cancer PSP: Priority 10 from the James Lind Alliance Womb Cancer PSP
Priority 11 from the Womb Cancer PSP: Priority 11 from the James Lind Alliance Womb Cancer PSP
Priority 12 from the Womb Cancer PSP: Priority 12 from the James Lind Alliance Womb Cancer PSP
Priority 13 from the Womb Cancer PSP: Priority 13 from the James Lind Alliance Womb Cancer PSP
Priority 14 from the Womb Cancer PSP: Priority 14 from the James Lind Alliance Womb Cancer PSP
Priority 15 from the Womb Cancer PSP: Priority 15 from the James Lind Alliance Womb Cancer PSP
Priority 16 from the Womb Cancer PSP: Priority 16 from the James Lind Alliance Womb Cancer PSP
Priority 17 from the Womb Cancer PSP: Priority 17 from the James Lind Alliance Womb Cancer PSP
Priority 19 from the Womb Cancer PSP: Priority 19 from the James Lind Alliance Womb Cancer PSP
Priority 20 from the Womb Cancer PSP: Priority 20 from the James Lind Alliance Womb Cancer PSP
Priority 21 from the Womb Cancer PSP: Priority 21 from the James Lind Alliance Womb Cancer PSP
Priority 22 from the Womb Cancer PSP: Priority 22 from the James Lind Alliance Womb Cancer PSP
Priority 24 from the Womb Cancer PSP: Priority 24 from the James Lind Alliance Womb Cancer PSP
Priority 25 from the Womb Cancer PSP: Priority 25 from the James Lind Alliance Womb Cancer PSP
Priority 26 from the Womb Cancer PSP: Priority 26 from the James Lind Alliance Womb Cancer PSP
Priority 27 from the Womb Cancer PSP: Priority 27 from the James Lind Alliance Womb Cancer PSP
Priority 23 from the Womb Cancer PSP: Priority 23 from the James Lind Alliance Womb Cancer PSP

Setting priorities for social care research in Wales

Top 10s

The Top 10 priorities for future research identified by each PSP, a collaboration between clinicians and patients to identify research priorities.

JLA Guidebook

The JLA Guidebook will help you through the priority setting process. Containing everything you need to understand a PSP, or run your own.

1. Introduction

The JLA Guidebook is aimed at people that are interested in the JLA’s priority setting process: namely, patients and their carers, clinicians

The James Lind Alliance

The James Lind Alliance (JLA) is a non-profit making initiative which was established in 2004. It brings patients, carers and clinicians together in Priority Setting Partnerships (PSPs) to identify and prioritise the unanswered questions about the effects of treatments that they agree are most important.

Contact us: Contact us The James Lind Alliance The Wessex Institute ...

Acknowledgements

Acknowledgements of individuals involved in the writing of the JLA Guidebook.

2. James Lind Alliance Methods and Principles

Why involve patients and clinicians in setting research priorities? ...

Why the JLA method?

Learn more about the principles of the JLA.

What is a Priority Setting Partnership?

The aim of PSPs is to bring patients, carers ...

Who's who in the Priority Setting Partnership?

The structure and role of people in a Priority Setting Partnership.

What are the principles of the JLA?

The JLA priority setting method is flexible and responsive ...

Exclusions: Traditionally the health research agenda has been largely determined ...

What are evidence uncertainties?

The JLA definition of an evidence uncertainty is that: no ...

JLA Advisers

What's the role of a JLA Adviser? They support and guide the PSP, neutrally, ensuring that the process is followed in a fair, transparent way

3. How to establish a PSP

Includes the JLA's definition of treatment uncertainty and links to articles about treatment uncertainty

Roles & responsibilities

Being a PSP leader - what's involved?

The PSP lead: All PSPs require good leadership and a considerable time ...
The PSP Coordinator: What does a PSP Project Coordinator do? How much work is it?
The Information Specialist: What does a PSP Information Specialist do? What skills does the Information Specialist need?
The PSP Steering Group: What does a PSP Steering Group do? Includes a template Steering Group Terms of Reference document for PSPs to adapt

What are the costs involved in running a PSP?

How much does it cost to run a PSP? What might you need to spend money on?

How long does a PSP take?

Information on the time taken to run a PSP, with an example timetable

Example: The JLA website shows a completed timetable from the Alcohol-Related ...

4. Setting up a PSP

How to start setting up a PSP Steering Group of key people who collectively can represent all or the majority of issues. Includes links to documents needed.

Agreeing scope and protocol

Ideas for when thinking about the scope of a PSP. Implications of decisions made. With links to examples of protocols from previous PSPs.

Identifying and managing partners/stakeholders

When setting up a PSP it is essential to identify partners and the patients, carers and clinicians affected by the health topic being considered.

Example: An organisation's participation is likely to be encouraged if ...

Initial awareness or scoping meeting

It's optional, but some PSPs hold an initial awareness or launch meeting to raise the profile of the PSP among patient and clinician groups

Example: To save costs, it may be possible to run ...

Managing the PSP

Things to agree on within the PSP, to help everyone to work in a consultative and inclusive way.

Appreciating values and perspectives: Encouraging equal valuation of views from all PSP participants
Communications: Ideas for communications around PSPs, including using the JLA brand
Working with patients and carers: Tips for inclusive communication and involvement
Working with clinicians: Ideas for involving clinicians in the PSP

5. Gathering uncertainties

Where should PSPs gather their uncertainties from? How many should they aim for? Including examples of how this has been done

Example

Here are some examples of how PSPs have promoted ...

How many responses is enough?

There is no recommended maximum or minimum number of ...

Example: It is important for Steering Groups to be realistic ...

Survey design

Developing a PSP questionnaire, with examples

Survey duration

The duration of a PSP survey should allow enough time to generate enough responses to cover as many themes as possible.

Consent and ethics

Using personal data and information about ethics approval

Searching existing literature for uncertainties

Documented sources of information need to be searched for evidence of uncertainty during the prioritisation exercise.

6. Data processing & verifying uncertainties

The detailed steps involved in the data management for a Priority Setting Partnership with examples of numbers of survey respondents

Stage 1. Download the survey data

Advice on organising PSP data, with a link to a template for this

Stage 2. Remove out-of-scope submissions

Advice on what to do with out-of-scope survey submissions

Example: The Sight Loss and Vision PSP agreed to send ...

Stage 3. Categorise eligible submissions

Once out-of-scope submissions have been identified and removed, PSPs may allocate the remaining submissions into categories, also known as a taxonomy.

Stage 4. Form indicative questions

Submissions for the PSP may need to be rewritten or rephrased to clarify the precise uncertainty and to make it easier to check against the evidence base.

Rephrasing and combining the submissions: It is important to note that the questions written ...
Finalising the long list of indicative questions: This process can be time consuming and labour intensive. ...

Stage 5. Verify the uncertainties

Each uncertainty submitted, including indicative uncertainties of combined submissions as described above, needs to be verified as a true uncertainty.

Identifying research recommendations: The searched systematic reviews and guidelines may contain research ...
Ongoing trials and studies: Some PSPs have considered the presence of ongoing trials ...

Preparing uncertainties for prioritisation and publication on the JLA website

To manage the data throughout the PSP process, it ...

Summary of data management steps

Stage 1: Download the survey data May be completed by ...

7. Interim priority setting

Ideas about how to present an interim priority setting survey

The number of questions to include

From experience, a maximum of around 60-70 indicative questions ...

Example: The Stillbirth PSP used the following criteria to help ...

Who should complete it?

Those asked to complete the interim prioritisation survey may ...

Approaches used

The main three methods used by a PSP to ask for interim priorities

Examples of interim priority setting

The Mesothelioma PSP listed 52 questions in the interim survey ranking them i order of importance.

Collating and scoring interim priorities

Completed interim prioritisation results should be grouped into categories and separate scores kept to ensure a fair weighting of the constituent groups.

8. Final priority setting

What are the principles of final priority setting in a JLA PSP?

Final priority setting method

Why the JLA supports an adapted Nominal Group Technique for PSPs choosing their top 10 priorities.

Who should take part: Those eligible to take part in a JLA priority ...

Preparing for the workshop

A summary of steps required in organising the meeting for the final workshop and the materials needed

Example: It is important for the Steering Group to think ...
Workshop observers: It is not unusual for observers to be invited ...

Workshop process on the day

What happens in a standard JLA final priority setting meeting?

Workshop best practice: The ground rules involved in a JLA PSP final workshop

Feedback from the final workshop participants

Evaluating the workshop helps JLA PSPs understand how the process has worked for them and to address any individual concerns.

9. Dissemination and publishing of the Top 10

It is important for PSPs to publicise and disseminate the results of their priority setting exercise to reach potential funders and researchers.

Example: The Coeliac Disease PSP Top 10 announcement included personal ...
JLA reporting requirements: A key principle of the JLA is transparency of ...

10. Taking priorities to research funders

How to disseminate priorities to researchers and research funders. What extra work is needed?

Example: After the Cystic Fibrosis PSP agreed its Top 10, ...
Finding appropriate research funders: Funders of research with the appropriate interests in addressing treatment uncertainties can be found in both the public and the charitable sector.
Communicating with appropriate researchers: Ideas for searching for researchers or their networks
Thinking about communicating your PSP priorities to the NIHR: PSPs have benefitted from discussing potentially fundable research priorities with the NIHR.

11. Follow up

After the final workshop, you can provide feedback to the JLA in a short survey. Your long term involvement in evaluating the impact of a PSP is important.

Example: An ‘After the Top 10 – bringing community priorities ...

12. Toolbox of key PSP documents

Link to documents which provide more useful information and examples of work done by previous PSPs.

News and Publications

The latest news from our PSPs, collaborations between patients, carers and clinicians to prioritise health research questions.

Newsletters: James Lind Alliance newsletters
JLA articles and publications: Articles published by the James Lind Alliance
PSP articles and publications: Articles published by the James Lind Alliance about Priority Setting Partnerships
PSP final reports: This section provides links to final reports that have ...

Contact us

Contact details for the James Lind Alliance.

Cookie policy

Information on the cookie policies of the James Lind Alliance.

Sitemap

The structure of the James Lind Alliance website

Copyright

All materials written for this website by the JLA ...

Making a difference

How JLA PSPs are making a difference to research

Funded Research: A summary of research that has been funded as a direct results of a James Lind Alliance Priority Setting Partnership
Working with the priorities: Many people do more work with PSP priorities to explore them even further
Reporting on results and impact: What have JLA PSPs done to track the response to their research priorities?

Current surveys

These are surveys currently available from James Lind Alliance Priority Setting Partnerships for patients, carers and health professionals to take part in

Mailing list

The JLA infrastructure is funded by the NIHR. Read our relationship statement.