Priority 16 from the Blood Pressure in Pregnancy PSP

UNCERTAINTY: What are the fetal, infant and child outcomes in women taking antihypertensive agents?  (JLA PSP Priority 16)
Overall ranking 16
JLA question ID 0099/16
Explanatory note Not available for this PSP

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta-Analysis.Webster LM, Conti-Ramsden F, Seed PT, Webb AJ, Nelson-Piercy C, Chappell LC.J Am Heart Assoc. 2017 May 17;6(5). pii: e005526. doi: 10.1161/JAHA.117.005526. Review.PMID:28515115

In-utero exposure to antihypertensive medication and neonatal and child health outcomes: a systematic review.Fitton CA, Steiner MFC, Aucott L, Pell JP, Mackay DF, Fleming M, McLay JS.J Hypertens. 2017 Nov;35(11):2123-2137. doi: 10.1097/HJH.0000000000001456. Review.PMID:28661961

Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.Abalos E, Duley L, Steyn DW.Cochrane Database Syst Rev. 2014 Feb 6;(2):CD002252. doi: 10.1002/14651858.CD002252.pub3. Review. Update in: Cochrane Database Syst Rev. 2018 Oct 01;10:CD002252. PMID:24504933

Health Research Classification System category Reproductive health and childbirth
Extra information provided by this PSP
Original uncertainty examples Are there any studies explaining what ranges of BP are associated with low birth weight or premature birth? ~ Drugs and outcomes to baby what are the best medications for controlling blood pressure in pregnancy, both for short term and longer term benefits for mother and baby? ~ What are the long term affects of the anti hypertensive medication on the baby? 
Submitted by 4 women, 3 healthcare, 2 researcher, 6 other 
PSP information
PSP unique ID 0099
PSP name Blood Pressure in Pregnancy
Total number of uncertainties identified by this PSP.

50 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)

Date of priority setting workshop 20 June 2019