Priority 18 from the Psoriatic Arthritis PSP

UNCERTAINTY: How do changes in female hormones, such as during puberty, pregnancy, menstruation, miscarriage, menopause, breast feeding and contraceptive use, trigger or affect psoriatic arthritis and its treatment? (JLA PSP Priority 18)
Overall ranking 18
JLA question ID 0108/18
Explanatory note This question, therefore, aims to generate evidence to fill these gaps to understand if significant differences exist in females with psoriatic arthritis. We already know that the disease is different for men and women but more information is needed. For example, is there a link between a woman's menstrual cycle and joint inflammation and pain intensity? Are there differences in the presentation of psoriatic arthritis between men and women? If so, could this lead to delays in diagnosis? What is the relationship between menopause and psoriatic arthritis? 

This is an area of uncertainty. No systematic reviews or guidelines identified. 

Health Research Classification System category Inflammatory and immune system
Extra information provided by this PSP
Original uncertainty examples Is there a link between intensity of joint inflammation and pain and a womans menstrual cycle?
Submitted by 9 uncertainties submitted 
PSP information
PSP unique ID 0108
PSP name Psoriatic Arthritis
Total number of uncertainties identified by this PSP. 46  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 12 July 2021