Priority 2 from the Mitochondrial Disease PSP

UNCERTAINTY: Can the damage to cells caused by mitchondrial disease be repaired (e.g. to restore hearing, vision or repair the pancreas)? (JLA PSP Priority 2)
Overall ranking 2
JLA question ID 0095/2
Explanatory note  Not available
Evidence

 None identified
Health Research Classification System category Metabolic and Endocrine
Extra information provided by this PSP
Original uncertainty examples Is it possible to repair damage to motor pathways caused by mitochondrial disease? ~ Development of nano tech to identify specific  areas being affected by mito and to fix or replace damaged cells. E.g hearing, repairing cells in the ears. Diabetes caused by mito, identify how to repair/replace damaged pancreas. ~ If no effective treatment is possible, then can we develop techniques (eg using stem cells) to restore RGCs/vision once optic atrophy has occurred? ~ Viability of stem cell therapies, and similar? 
Submitted by Patient x 2, Carer x 1, Healthcare Professional x1
PSP information
PSP unique ID 0095
PSP name Mitochondrial Disease
Total number of uncertainties identified by this PSP. 42  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 19 January 2020