Priority 9 from the Blood Transfusion and Blood Donation PSP

UNCERTAINTY: What medical conditions make it unsafe for a person to be a blood donor? (JLA PSP Priority 9)
Overall ranking 9
JLA question ID 0063/9
Explanatory note Not available for this PSP
Evidence 1. Pasricha S, Speedy J, Low M. What do systematic reviews of iron supplementation in women tell us about the functional consequences of donor iron deficiency? Vox Sanguinis. 2015;109((Suppl. 1)):58-.
2. Hoogerwerf MD, Veldhuizen IJ, De Kort WL, Frings-Dresen MH, Sluiter JK. Factors associated with psychological and physiological stress reactions to blood donation: a systematic review of the literature. Blood Transfusion. 2015;13(-3):354-62.
3.Estcourt LJ, Malouf R, Hopewell S, Trivella M, Doree C, Stanworth SJ, Murphy MF. Pathogen-reduced platelets for the prevention of bleeding. Cochrane Database of Systematic Reviews 2017, Issue 7. Art. No.: CD009072. DOI: 10.1002/14651858.CD009072.pub3.
4. Chasse M, McIntyre L, English SW, Tinmouth A, Knoll G, Wolfe D, et al. Effect of blood donor characteristics on transfusion outcomes: a systematic review and meta-analysis. Transfusion Medicine Reviews. 2016.
5. Chasse M, Tinmouth AT, English SW, McIntyre L, Knoll G, Wolfe D, et al. Effect of blood donor characteristics on transfusion outcomes: a systematic review and meta-analysis. Transfusion. 2015;55((Suppl. 3)):123A-A.
6. De Buck E, Dieltjens T, Compernolle V, Vandekerckhove P. Is having sex with other men a risk factor for transfusion-transmissible infections in male blood donors in Western countries? A systematic review. PLoS ONE [Electronic Resource]. 2015;10(4):e0122523-e.
7. Webster J, Bell-Syer SE, Foxlee R. Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion. Cochrane Database of Systematic Reviews. 2015(2):CD007948-CD.
Health Research Classification System category Generic Health Relevance
Extra information provided by this PSP
Original uncertainty examples Are the donor exclusion criteria truly evidence based? ~ When is safe to donate blood after contacting hepatitis A? ~ Why do I need to wait after travelling abroad if I have not been unwell or vaccinated? ~ Can a person with HIV be able to donate blood? ~ What are the criteria for being able to donate blood? ~ I have a blood cancer, how would it be picked up if I tried to donate blood?
Submitted by 7 blood recipients ~ 10 relative or carers of blood recipients ~ 21 blood donors ~ 13 health professionals ~ 4 unknown
PSP information
PSP unique ID 0063
PSP name Blood Transfusion and Blood Donation
Total number of uncertainties identified by this PSP 51  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 28 February 2018