Priority 15 from the Autosomal Dominant Polycystic Kidney Disease Project

UNCERTAINTY: Does early treatment of high blood pressure improve the long-term health of people with ADPKD and/or reduce the risk of thickened heart walls (left ventricular hypertrophy)?  (Priority 15
Overall ranking 15
JLA question ID 0103/15
Explanatory note Not available for this PSP

No evidence identified

Health Research Classification System category  Renal and urogenital
Extra information provided by this project
Original uncertainty examples How effective are Angiotensin converting enzyme inhibitors (ACEi) compared to Angiotensin Receptor Blockers (ARB), in people with ADPKD, for first-line treatment of blood pressure control? ~ What is the benefit of low blood pressure targets in people with early stage ADPKD or with left ventricular hypertrophy? ~ What are the benefits and harms of formal screening for hypertension in children with ADPKD; when benefits outweigh harms; at what age should screening be started in and what is the recommended frequency of screening? ~ What are the benefits and harms of detecting and treating prehypertension (BP 90-95th or even 75-95th percentile) in children with ADPKD?
Submitted by Autosomal Dominant Polycystic Kidney Disease (ADPKD): Report from a Kidney Disease Improving Global Outcomes (KDIGO) Controversies Conference 
Project information
Project unique ID 0103
Project name Autosomal Dominant Polycystic Kidney Disease
Total number of uncertainties identified by this project.

35 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)

Date of priority setting workshop 15 December 2020