Progressive Pulmonary Fibrosis Top 10

  1. How can the diagnosis of PPF (Progressive Pulmonary Fibrosis) be improved in terms of accuracy and the time taken (screening programme, early signs and symptoms that could be detected in primary care, blood markers, imaging, biopsy, artificial intelligence, etc.)?
  2. Can new treatments other than pirfenidone and nintedanib slow, halt or reverse the progression of PPF?
  3. What can be done to improve the speed and accuracy of PPF diagnosis in primary care (e.g. training, integration of case-based studies in GP training, awareness campaigns)?
  4. What is the best time for drug and non-drug interventions (pulmonary rehab, oxygen therapy, psychological support) to start to preserve quality and length of life for patients with PPF?
  5. What are the best ways (drug, non-drug and aids) to treat cough in PPF?
  6. Would early treatment delay progression, lung function decline, and improve survival in PPF?
  7. Which therapies will improve survival in PPF?
  8. What treatments (drug, non-drug and aids) can reduce breathlessness and phlegm production in PPF?
  9. To what extent do different interventions (pulmonary rehab, oxygen therapy, psychological support) impact length of life in patients with PPF?
  10. Can new treatments for PPF be developed with reduced side effects? Does how the drug is delivered (e.g. oral, nebulised, through a vein) affect potential side effects of the drug in PPF?