Priority 6 from the Kidney Transplant PSP

UNCERTAINTY: What are the long-term health risks to the living kidney donor?
Overall ranking Priority questions agreed on but not put in ranked order
JLA question ID 0037/6
Explanatory note Not available for this PSP
Evidence

Existing Randomised Controlled Trials: Geir Mjoen et al. Long-term risks for kidney donors. Kidney International (2014) 86, 162-167; doi:10.1038/ki.2013.460 ~
Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, McBride MA, Montgomery RA. Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010 Mar 10;303(10):959-66.

Health Research Classification System category Renal and Urogenital
Extra information provided by this PSP
Original uncertainty examples

What are the long term implications (medical and psychological) for living donors? Are there any long-term health problems for living donors? What long term effects will I notice living with one kidney? What is the evidence base for the long term health implications of a living donor? if I give my kidney away to a stranger, will my life be affected in any way, will it shorten my life span? if I give my kidney away to a stranger, will my life be affected in any way, will it shorten my life span? What are the long term effects of having only one normal kidney? What, if any, are the long term effects of living with one kidney after donation and are there any medications which should be avoided? As a kidney donor, should I expect any permanent changes to my health or lifestyle? As a kidney donor, what would happen if I develop kidney disease e.g. could I have a transplant? What is the long term outcome, and what are the consequences for living kidney donors? What are the risks for living donors? 
Comparison Surgery
Submitted by Patients x 16 Clinicians x 3
Outcomes to be measured Rate of renal failure, hypertension, cardiovascular events, patient survival.
PSP information
PSP unique ID 0037
PSP name Kidney Transplant
Total number of uncertainties identified by this PSP. 90  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 3 February 2016