Priority 15 from the Mitochondrial Disease PSP

UNCERTAINTY: Is there a way to predict who will become ill with mitochondrial disease, and whose symptoms will be worse? (JLA PSP Priority 15)
Overall ranking 15
JLA question ID 0095/15
Explanatory note  Not available

 None identified

Health Research Classification System category Metabolic and Endocrine
Extra information provided by this PSP
Original uncertainty examples LHON - how can we predict who will get clinical disease ~ What are the chances of symptom progression depending on % of mutation? ~ Is there a way to predict the severity of the disease in infants of parents with Mitochondrial Disease? ~ Can a test be developed that predicts the chances of a carrier going blind? ~ Is there a benefit to establishing percentage mutation load in a particular patient? ~ Understanding of predictive factors
Submitted by  3 x Healthcare Professional, 2 x Patient, 1 x Carer
PSP information
PSP unique ID 0095
PSP name Mitochondrial Disease
Total number of uncertainties identified by this PSP. 42  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 19 January 2020