Priority 9 from the Liver Glycogen Storage Disease (International) PSP

UNCERTAINTY: What are the long-term complications (liver, renal, gut) of a diet rich in uncooked cornstarch and/or high protein and should the diet be adjusted to prevent complications in liver Glycogen Storage Disease?  (JLA PSP Priority 9)
Overall ranking 9
JLA question ID 0090/9
Explanatory note

Cornstarch therapy is a modus of treatment in which a large part of the diet consists of carbohydrate therapy, which could possibly lead to complications associated with high carbohydrate intake, such as weight gain or diabetes mellitus. This question focusses on identification and prevention of situations in which cornstarch therapy leads to these complications. 


For details of the evidence checked, please see the spreadsheet held on the JLA website.

Health Research Classification System category Metabolic and endocrine 
Extra information provided by this PSP
Original uncertainty examples What effects to cornstarch/Glycosade have on long-term health? ~ Is the high amount of uncooked corn starch going to cause problems long term? ~ Which affectation can have the kidneys with the high consumption of protein? ~ Does the corn starch and glycosade effect the liver and kidneys due to how much daily intake they have. ~ What effects to cornstarch/Glycosade have on long-term health? 
Submitted by Patient, carer and healthcare professionals
PSP information
PSP unique ID 0090
PSP name International Glycogen Storage Disease PSP
Total number of uncertainties identified by this PSP 72  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 24 May 2019