Priority 19 from the Anaesthesia (Canada) PSP

UNCERTAINTY: What is the relationship between anesthetic drugs and post-operative cognitive dysfunction and memory loss in patients?  (JLA PSP Priority 19)
Overall ranking 19
JLA question ID 0084/19
Explanatory note

This question asks about how anesthesia medications affect brain function and memory. Respondents wanted to know about the impacts of anesthesia for brain function of people of all ages.


Miller D, Lewis SR, Pritchard MW, Schofield-Robinson OJ, Shelton CL, Alderson P, Smith AF. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. Cochrane Database Syst Rev. 2018 Aug 21;8.

Health Research Classification System category  Generic health relevance
Extra information provided by this PSP
Original uncertainty examples Is an elderly patient at increased risk of developing dementia due to the use of general anesthetic? ~ What is the relationship between our anesthetic drugs and postoperative cognitive dysfunction and memory loss  in all ages of pts.?
Submitted by Healthcare providers, caregivers, patients
PSP information
PSP unique ID 0084
PSP name Anesthesia (Canada)
Total number of uncertainties identified by this PSP. 49  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 15 May 2019