Priority 8 from the Rare Musculoskeletal Diseases in Adulthood PSP

UNCERTAINTY: How do rare metabolic bone disorders progress as people grow older and how is this different from normal ageing? (JLA PSP Priority 8)
Overall ranking 8
JLA question ID 0076/8
Explanatory note Not available for this PSP
Evidence

Monostotic fibrous dysplasia of the proximal femur: natural history and predisposing factors for disease progression. Han I1, Choi ES, Kim HS. Bone Joint J. 2014 May;96-B(5):673-6
Health Research Classification System category Musculoskeletal
Extra information provided by this PSP
Original uncertainty examples What is the natural history of these conditions? ~ At what age do the dental problems usually abate? Is there much research on dental problems continuing in adulthood? ~ Why is the impact on adult teeth not considered a risk by the profession? ~ What is known about the impact of XLH and the ageing process? What is likely to go wrong and when is it likely to happen?
Submitted by Individual survey submissions categorised by Health or Social Care Professionals, Organisations representing people with rare musculoskeletal diseases, people with rare musculoskeletal diseases, relatives/carers/friends, Other.  For full details of the type of submitter for each individual question, please see the spreadsheet of data held on the JLA website.
PSP information
PSP unique ID 0076
PSP name Rare Musculoskeletal Diseases in Adulthood
Total number of uncertainties identified by this PSP. 39  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 18 June 2018