Priority 7 Stroke Prevention, Diagnosis, Pre-hospital and Hospital Care

UNCERTAINTY: What are the processes that cause delayed changes in brain function (neurological deficit) after subarachnoid haemorrhage caused by an aneurysm?   (JLA PSP Priority 7)
Overall ranking 7
JLA question ID 0106/7a
Explanatory note

Subarachnoid haemorrhages (SAH) are often caused by a burst blood vessel in the brain (a ruptured brain aneurysm) [Ref. 7].

Aneurysmal SAH affects six to nine people per 100,000 per year, has a 35% mortality, and leaves many with lasting disabilities, often related to cognitive dysfunction [Ref. 8]. Delayed ischemic neurologic deficit (DIND) is the main preventable cause of poor outcomes in aneurysmal subarachnoid haemorrhage (SAH) patients [Ref. 9]. However, evidence is needed to understand the processes to develop treatments to prevent DIND.

Ref 7: https://www.nhs.uk/conditions/subarachnoid-haemorrhage/
Evidence

 No evidence identified
Health Research Classification System category Stroke
Extra information provided by this PSP
Original uncertainty examples What are the mechanisms underpinning onset of delayed neurological deficit after aneurysmal subarachnoid haemorrhage? 
Submitted by  Health/Social Care professional x 1
PSP information
PSP unique ID 0106
PSP name Stroke prevention, diagnosis, pre-hospital and hospital care
Total number of uncertainties identified by this PSP. 93  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 30th April 2021