Priority 8 from the Bleeding Disorders PSP

UNCERTAINTY: What are the genetic and environmental factors that predispose people to immune thrombocytopenic purpura (ITP)? (JLA PSP Priority 8)
Overall ranking 8
JLA question ID 0078/8
Explanatory note

The advances in genetic medicine in recent years has led to questions being asked in respect of most conditions. ITP is no different and the question has often been asked “is ITP caused by a genetic defect which is hereditary or due to a genetic defect at birth. Similarly, are there external environmental factors which may have an adverse effect on the body’s genetics or organs ? ”

There has been very little research undertaken into ITP being connected with either a genetic defect or external factors other than viral infections as being the possible cause of ITP. It is thought more consideration should be given into research into defective genetic structures within ITP patients and the effects of external factors such as pollution and viral transmission within the environment.

Evidence  No systematic reviews
Health Research Classification System category Blood
Extra information provided by this PSP
Original uncertainty examples Is ITP hereditary? ~ Finding out the cause of ITP would be great.  ~ What causes ITP?
Submitted by Not available
PSP information
PSP unique ID 0078
PSP name Bleeding Disorders
Total number of uncertainties identified by this PSP. 66 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 7 July 2018