Priority 12 from the Blood Pressure in Pregnancy PSP

UNCERTAINTY: What is the effectiveness and safety of antihypertensive agents at reducing blood pressure in women with pregnancy hypertension? (JLA PSP Priority 12)
Overall ranking 12
JLA question ID 0099/12
Explanatory note Not available for this PSP

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta-Analysis. Webster LM, Conti-Ramsden F, Seed PT, Webb AJ, Nelson-Piercy C, Chappell LC. J Am Heart Assoc. 2017 May 17;6(5). pii: e005526. doi: 10.1161/JAHA.117.005526. Review.

Antihypertensive drug therapy for women with non-severe hypertensive disorders of pregnancy: a systematic review and meta-analysis.Ogura S, Suzuki J, Suzuki H.Hypertens Res. 2019 May;42(5):699-707. doi: 10.1038/s41440-018-0188-0. Epub 2019 Jan 9.PMID:30626932

Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis.Shekhar S, Gupta N, Kirubakaran R, Pareek P.BJOG. 2016 Jan;123(1):40-7. doi: 10.1111/1471-0528.13463. Epub 2015 Jun 26. Review.PMID:26113232

Drugs for treatment of very high blood pressure during pregnancy.Duley L, Meher S, Jones L Cochrane Database Syst Rev. 2013 Jul 31;(7):CD001449. doi: 10.1002/14651858.CD001449.pub3. Review.PMID:23900968

Health Research Classification System category Reproductive health and childbirth
Extra information provided by this PSP
Original uncertainty examples What is the most effective and safe way to manage/lower high blood pressure in pregnancy to enable the pregnancy to reach full term? ~ what is the best way to reduce high blood pressure while pregnant ~ What is the best treatment for high blood pressure in pregnant ladies? ~ Is a one side fits all approach useful or should it be adapted to each woman? ~ What is the best treatment for hypertension in pregnancy? ~ How can this be managed effectively and safely ~ What´s the best treatment for high blood pressure in pregnancy? 
Submitted by 20 women, 26 healthcare, 2 researchers, 3 other, 1 literature review of uncertainties reported
PSP information
PSP unique ID 0099
PSP name Blood Pressure in Pregnancy
Total number of uncertainties identified by this PSP.

50 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)

Date of priority setting workshop 20 June 2019