Priority 1 from the Hyperemesis Gravidarum PSP

UNCERTAINTY: Can we find a cure? What novel or new treatments are being developed/tested/used elsewhere which could have a curative effect and to address all the symptoms of hyperemesis gravidarum rather than just the vomiting? (JLA PSP Priority 1)
Overall ranking 1
JLA question ID 0090/1
Explanatory note Not available for this PSP

Some small and novel trials identified for gabapentin, clonidine, mitrazepam, marijuana and other therapies. 

Health Research Classification System category Reproductive health and childbirth
Extra information provided by this PSP
Original uncertainty examples Is there a cure?  ~ Will there ever be a cure for this 'HG'? ~ is there not a surgical way or medical way to eradicate this reaction? ~ By what treatment can HG be totally cured? ~ This means de vomitting,  the nausea, lack of feeling hungry, etc. Given the 2 genes (contributing to appetite and placenta) which were recently found to be connected with the root causes of Hyperemesis Gravidarum, how can one reduce his / her chances of acquiring this sickness or cure it in an earlier stage than 20 weeks plus or the entire pregnancy? Please try to find a cure!!
Submitted by Patients x 52 ~ Healthcare professionals x 7 ~ Carers x 3 ~ Offspring x 6 ~ Organisational representatives x 2 ~ Unknown x 7 
PSP information
PSP unique ID 0090
PSP name Hyperemesis Gravidarum
Total number of uncertainties identified by this PSP. 65  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 9 October 2019