Priority 10 from the COPD Exacerbation PSP
|UNCERTAINTY: What are the risks and benefits of long-term antibiotics to prevent COPD exacerbations, and how should they be best used? (JLA PSP Priority 10)
|JLA question ID
|Antibiotics are sometimes used long-term in COPD not to treat, but to prevent exacerbations. This is called 'prophylaxis'. However, long term use might cause side-effects, or problems because the bacteria become resistant to the antibiotics. This question aims to understand the pros and cons of using antibiotics in this way, how to use them best and therefore to understand which patients are most likely to benefit from them.
The question has partially been addressed in the evidence base.
|Health Research Classification System category
|Extra information provided by this PSP
|Original uncertainty examples
Should more patients be on prophylactic steroids and/or antibiotics to prevent exacerbations? ~ To what extent does Long term prophylactic antibiotics affect the frequency or duration of exacerbations ~ To what extent does Antibiotics and /oral steroids started at the onset of exacerbation. affect the frequency or duration of exacerbations ~ I take azrthmycin as a preventative daily. I’m scared of antibiotic resistance. Trials of limited periods of different antibiotics to see if dependency lessons or immunity could be beneficial. ~ do I need to keep taking azithromycin ~ How long is it ok to take azithromycin as a prophylactic, I take it 3times a week
|Patient, Healthcare professional
|PSP unique ID
|COPD Exacerbation PSP
|Total number of uncertainties identified by this PSP.
|51 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
|Date of priority setting workshop
|1 April 2021