Priority 3 from the Multiple Sclerosis PSP

UNCERTAINTY: Which treatments are effective for fatigue in people with multiple sclerosis? (JLA PSP Priority 3)
Overall ranking 3
JLA question ID 0016/3
Explanatory note Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects

Tejani AM, Wasdell M, Spiwak R, Rowell G, Nathwani S. Carnitine for fatigue in multiple sclerosis. Cochrane Database of Systematic Reviews 2012, Issue 5. Art. No.: CD007280. DOI: 10.1002/14651858.CD007280.pub3.

Payne C, Wiffen PJ, Martin S. Interventions for fatigue and weight loss in adults with advanced progressive illness. Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD008427. DOI: 10.1002/14651858.CD008427.pub2.

Systematic reviews that need extending or updating

No reviews found

Systematic reviews in preparation

Heine M, Rietberg MB, van Wegen EEH, Port IVD, Kwakkel G. Exercise therapy for fatigue in multiple sclerosis (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009956. DOI: 10.1002/14651858.CD009956.

Ongoing controlled trials

TREating FAtigue in Multiple Sclerosis: Energy conservation management TREFAMS-E ISRCTN82353628

TREating FAtigue in Multiple Sclerosis: Aerobic training TREFAMS-A ISRCTN69520623

TREating FAtigue in Multiple Sclerosis: Cognitive behavioural therapy TREFAMS-C ISRCTN58583714

Health Research Classification System category Neurological
Extra information provided by this PSP
Original uncertainty examples No examples provided.  This is an indicative uncertainty and several submissions were merged to form this one. 
Submitted by 16 patients ~ 6 carers ~ 9 clinicians
Outcomes to be measured Management and or change of multiple sclerosis symptoms; adverse effects or complications; acceptability to patients or carers; time to return to work or normal activity; time in hospital and or needing health or social care services; health related quality of life; and costs.
PSP information
PSP unique ID 0016
PSP name Multiple Sclerosis
Total number of uncertainties identified by this PSP. 82  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop July 2013