Priority from the Bleeding Disorders PSP

UNCERTAINTY: Are there factors other than “the number of joint bleeds” that are associated with haemophilic arthropathy (joint damage)?  
Overall ranking This was one of the 15 questions at the workshop that fell outside of the Top 10. These were not ranked in any order of priority
JLA question ID 0078/23
Explanatory note The amount of joint damage varies between different patinets with haemophilia even when of the same severity. If we understood why this is we may be able to reduce the damage from bleeding. 
Evidence Schafer, GS, S Valderramas, AR Gomes, MB Budib, AL Wolff, AA Ramos. Physical exercise, pain and musculoskeletal function in patients with haemophilia: a systematic review. Haemophilia 22 (2016) e119-29.
Health Research Classification System category Blood
Extra information provided by this PSP
Original uncertainty examples Not available
Submitted by Not available
PSP information
PSP unique ID 0078
PSP name Bleeding Disorders
Total number of uncertainties identified by this PSP. 66 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 7 July 2018