Priority 27 from the Palliative and end of life care PSP

UNCERTAINTY:  What are the best treatments for nausea and vomiting (including for people with bowel obstruction and those having palliative chemotherapy)?    (JLA PSP Priority 27)
Overall ranking 27
JLA question ID 0026/27

Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD006271. DOI: 10.1002/14651858.CD006271.pub2.

Storrar J, Hitchens M, Platt T, Dorman S. Droperidol for treatment of nausea and vomiting in palliative care patients. Cochrane Database of Systematic Reviews 2014, Issue 11. Art. No.: CD006938. DOI: 10.1002/14651858.CD006938.pub3.  

Darvill E, Dorman S, Perkins P. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD009420. DOI: 10.1002/14651858.CD009420.pub2.

Ongoing trials: Efficacy of Thalidomide in Preventing Chemotherapy-induced Delayed Nausea and Vomiting NCT02203253  

Effectiveness of Auricular Acupressure in the Treatment of Chemotherapy Induced Nausea and Vomiting in Ovarian Cancer and Endometrial Cancer

The effects of the Cardamom aroma on the nausea and vomiting induced by chemotherapy

Health Research Classification System category  Generic
Extra information provided by this PSP
Original uncertainty examples What is the best antiemetic for nausea and vomiting with specific causes?  ~  Out of hours emergency care, e.g for sudden onset of infections, is provided by my local specialist cancer hospital, first by a triage phone call, and then a decision as to whether I should come into hospital. But how do I deal with things such as nausea, tooth problems and debilitating pain, which can strike at any time (but typically do strike at weekends/pubic holidays)?  ~  Does olanzapine help with cachexia/ nausea?
Submitted by Bereaved Carers x 2  ~  Carer x 1     
Outcomes to be measured Health related quality of life, good death, Change in symptoms or change in management of symptoms, adverse effects or complications
PSP information
PSP unique ID 0026
PSP name Palliative and end of life care
Total number of uncertainties identified by this PSP. 83  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 21 November 2014