Priority 1 Sight Loss and Vision PSP Age Related Macular Degeneration

UNCERTAINTY: Can a treatment to stop dry age related macular degeneration (AMD) progressing and/or developing into the wet form be devised? (JLA PSP Priority 1)
Overall ranking 1
JLA question ID 0014a/1
Explanatory note Reliable up-to-date systematic reviews revealed important continuing uncertainties about treatment effects at the time of the PSP
Evidence Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD000253. DOI: 10.1002/14651858.CD000253.pub3 Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000254. DOI: 10.1002/14651858.CD000254.pub3 Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010015. DOI: 10.1002/14651858.CD010015.pub2 Evans JR. Ginkgo biloba extract for age-related macular degeneration. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD001775. DOI: 10.1002/14651858.CD001775.pub2.
Health Research Classification System category Eye
Extra information provided by this PSP
Original uncertainty examples Age Related Macular Degeneration Rank 1 Are there any known cures for dry age-related macular degeneration? Are there any prospects for treatment of dry age-related macular degeneration? Are there any treatments available for dry age-related macular degeneration? Are we getting close to a cure for both wet and dry age-related macular degeneration? Do we have any improvement in the treatment for dry age-related macular degeneration? How can dry age-related macular degeneration be treated? How can we develop an effective treatment for dry age related macular degeneration (AMD)? Why is it that (treatment for) wet age-related macular degeneration has made spectacular advances in the past few years, whereas (treatment for) dry age-related macular degeneration has made little progress? Why is there no treatment for dry age-related macular degeneration?
Systematic reviews that need updating or extending None identified
Systematic reviews in preparation (at time of PSP)

Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD000253. DOI: 10.1002/14651858.CD000253.pub3

Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000254. DOI: 10.1002/14651858.CD000254.pub3

Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010015. DOI: 10.1002/14651858.CD010015.pub2

Evans JR. Ginkgo biloba extract for age-related macular degeneration. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD001775. DOI: 10.1002/14651858.CD001775.pub2.
Ongoing controlled trials None identified
Submitted by Clinicians
Outcomes to be measured Change in symptoms; adverse effects or complications; acceptability to the patient; and cost
PSP information
PSP unique ID

0014a
PSP name Sight Loss and Vision - Age Related Macular Degeneration
Total number of uncertainties identified by this PSP. 113  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop April and May 2013