Priority 8 from the Multiple Sclerosis PSP

UNCERTAINTY: Which treatments are effective to improve cognition in people with multiple sclerosis? (JLA PSP Priority 8)
Overall ranking 8
JLA question ID 0016/8
Explanatory note Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects

He D, Zhou H, Guo D, Hao Z, Wu B. Pharmacologic treatment for memory disorder in multiple sclerosis. Cochrane Database of Systematic Reviews 2011, Issue 10. Art. No.: CD008876. DOI: 10.1002/14651858.CD008876.pub2.

das Nair R, Ferguson H, Stark DL, Lincoln NB. Memory rehabilitation for people with multiple sclerosis. Cochrane Database of Systematic Reviews 2012, Issue 3. CD008754. DOI: 10.1002/14651858.CD008754.PUB2. Rosti-Otaj?rvi EM, H?m?l?inen PI.

Neuropsychological rehabilitation for multiple sclerosis. Cochrane Database of Systematic Reviews 2011, Issue 11. Art. No.: CD009131. DOI: 10.1002/14651858.CD009131.pub2.

Systematic reviews that need extending or updating

No evidence

Systematic reviews in preparation

No evidence

Ongoing controlled trials

Walking While Talking: The Effect of Doing Two Things at Once in Individuals With Neurological Injury or Disease NCT01917903.

Mindfulness Intervention for Multiple Sclerosis (MIMS) MIMS ISRCTN93263909 Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis REACTIV NCT01207856

Health Research Classification System category Neurological
Extra information provided by this PSP
Original uncertainty examples No examples provided.  This is an indicative uncertainty and several submissions were merged to form this one. 
Submitted by 5 patients ~ 3 carers ~ 2 clinicians
Outcomes to be measured Management and or change of multiple sclerosis symptoms; adverse effects or complications; acceptability to patients or carers; time to return to work or normal activity; time in hospital and or needing health or social care services; health related quality of life; and costs.
PSP information
PSP unique ID 0016
PSP name Multiple Sclerosis
Total number of uncertainties identified by this PSP. 82  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop July 2013