Priority 11 from the Advanced Heart Failure PSP

UNCERTAINTY: Which approaches are effective in reducing fatigue in people with advanced heart failure? (JLA PSP Priority 11)
Overall ranking 11
JLA question ID 0098/11
Explanatory note

Whilst there is some intervention research focusing on fatigue with advanced heart failure, much of it is not,and there is much more focus on functional improvement and to a lesser extent broad quality of life measures.


1.JBI Database System Rev Implement Rep. 2016 Mar; 14(3):68-115. doi: 10.11124/JBISRIR-2016-2441.Experiences and management of fatigue in everyday life among adult patients living with heart failure: a systematic review of qualitative evidence. Schjoedt I, Sommer I, Bjerrum MB.

2. Heart Fail Rev. 2016 Sep; 21(5):579-90. doi: 10.1007/s10741-016-9558-3.
Effect of cardiac pacing on sleep-related breathing disorders: a systematic review.Anastasopoulos DL, Chalkias A, Iakovidou N, Xanthos T.

3. Sleep Med. 2016 Jan; 17:149-57. doi: 10.1016/j.sleep.2015.10.017. Epub 2015 Dec 2. Nocturnal oxygen therapy in patients with chronic heart failure and sleep apnea: a systematic review. Bordier P, Lataste A, Hofmann P, Robert F, Bourenane G.

4. Eur J Heart Fail. 2010 Feb;12(2):137-47. doi: 10.1093/eurjhf/hfp194. Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review. Johnson MJ, Oxberry SG, Cleland JG, Clark AL.

Health Research Classification System category  Cardiovascular
Extra information provided by this PSP
Original uncertainty examples What can help with tiredness? ~ What can be done to improve fatigue in heart failure? ~ What can help them get more energy?  ~ How is heart failure likely to affect my day to day life? Is there anything I can do to help with tiredness caused by heart failure? ~ What are the best ways to manage breathlessness caused by heart failure? ~ Which interventions work best for fatigue? ~ How can we manage your fatigue best?  ~ Are there any treatments which relieve fatigue? ~ What can help the hf patient sleep better?
Submitted by  11 x health professionals, 3 x carers, 2 x patients 
PSP information
PSP unique ID 0098
PSP name Advanced Heart Failure
Total number of uncertainties identified by this PSP. 65  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 13 February 2019