Priority 6 from the Psoriasis PSP

UNCERTAINTY: Does treating psoriasis help improve other health conditions, such as psoriatic arthritis, cardiovascular disease, metabolic syndrome and stress? (JLA PSP Priority 6)
Overall ranking 6
JLA question ID 0072/6
Explanatory note Not available for this PSP

Abbott, 2015 Evidence that TNF-α inhibitor therapy reduces depression in people who have chronic diseases (including those with psoriasis) though the effects are small.    Limited data available.  Further studies investigating a more detailed timeline of changes in depression, inflammatory biomarkers and disease activity status in patients with psoriasis (and other chronic diseases) are required. 

Armstrong 2013a Some evidence that mild and severe psoriasis is associated with an increased risk of myocardial infarction and stroke.  Severe psoriasis is also associated with an increased risk of cardiovascular mortality.  Some limitations.  Future studies needed - these should include more complete covariate adjustment and characterisation of psoriasis severity. 

Armstrong 2013b Evidence that psoriasis and psoriatic arthritis are associated with greater prevalence of hypertension.  Patients with severe psoriasis have greater odds of hypertension than those with mild psoriasis.  Some limitations with study.  Further studies are needed – specifically to elucidate the basic mechanisms underlying the association between psoriasis and hypertension, to explore the relationship between psoriasis and hypertension severity, and to examine the effects of systemic treatments for psoriasis on hypertension control. 

Please see the data sheet for further list of evidence considered.

Health Research Classification System category Skin
Extra information provided by this PSP
Original uncertainty examples Does the use of biologics for psoriasis interfere with control or treatment of Diabetes?
Submitted by 24 uncertainties were submitted around this question
PSP information
PSP unique ID 0072
PSP name Psoriasis
Total number of uncertainties identified by this PSP. 55  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 17 September 2018