Priority 12 from the Alcohol-related Liver Disease PSP

UNCERTAINTY: What are the factors that determine who gets significant/advanced alcohol-related liver disease (affect progression)? (JLA PSP Priority 12)
Overall ranking 12
JLA question ID 0044/12
Explanatory note (including examples of original survey submissions) It is well recognised that although the more alcohol a person drinks the more likely they are to get alcohol-related liver disease, there is a large variation in susceptibility to this condition. A knowledge of the factors that affect the risk to an individual is important for the individual to understand as well as for healthcare professionals in order that they may provide advice tailored to that person. Some factors are genetic, but other factors are likely to be dietary as well as other unknown elements. Genetic factors are the main interest here: "Can you be genetically pre-dispositioned - either to be dependent or to be more susceptible to liver damage from drinking? "  Though some other issues are raised:   "Is there any evidence that some people are more susceptible to alcohol-related liver disease and, if so, is it useful to communicate this to patients?"     "What are the gender differences in determinants and consequences of a diagnosis of ARLD?"
Evidence None identified
Health Research Classification System category Oral and Gastrointestinnal
Extra information provided by this PSP
Submitted by 4 patients, 8 carers and 29 professionals
PSP information
PSP unique ID 0044
PSP name Alcohol-related Liver Disease
Total number of uncertainties identified by this PSP. 45 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 16 September 2016