Pernicious Anaemia

Pernicious anaemia is an autoimmune disease where patients are unable to absorb vitamin B12 from food. Normal healthy people will produce a substance called intrinsic factor in their stomach. Intrinsic factor facilitates the extraction of B12 from food, but people with pernicious anaemia produce an antibody that destroys their intrinsic factor and consequently will not be able to absorb B12 and consequently not be able to produce healthy red blood cells.

The Pernicious Anaemia PSP worked with patients, carers and clinicians to identify uncertainties about the diagnosis and management of pernicious anaemia and to agree by consensus a prioritised list of those uncertainties, for research.

The image below shows the PSP Steering Group at their first meeting on 17 November 2020.

The Pernicious Anaemia PSP Top 10 was published in December 2021.


See news from this PSP: April 2022

Key documents

Pernicious Anaemia PSP Protocol

Pernicious Anaemia PSP Question Verification Form

Pernicious Anaemia PSP Engagement summary