The purpose of this Question Verification Form is to enable Priority Setting Partnerships (PSPs) to describe clearly how they checked that their questions were unanswered, before starting the interim prioritisation stage of the process.
The JLA requires PSPs to be transparent and accountable in defining their own scope and evidence checking process. This will enable researchers and other stakeholders to understand how individual PSPs decided that their questions were unanswered, and any limitations of their evidence checking.
Name of the PSP
Pernicious Anaemia
Please describe the scope of the PSP
The scope of the Pernicious Anaemia PSP is uncertainties about the Cause, Diagnosis, Treatment and Care of Pernicious Anaemia, including:
- Identifying the uncertainties with the clinical definition of Pernicious Anaemia
- Identifying the uncertainties with the tests used to Diagnose Vitamin B12 Deficiency
- Identifying the uncertainties with the tests to Diagnose Pernicious Anaemia
- Identifying the uncertainties with the current management replacement therapy regimen
- Identifying the uncertainties with other replacement therapy delivery methods
Please provide a brief overview of your approach to checking whether the questions were unanswered
Given the limited amount of research in this area, we included reviews published in the last ten years. We applied the JLA standard of seeking relevant systematic reviews.
Please list the type(s) of evidence you used to verify your questions as unanswered
Systematic Reviews
Please list the sources that you searched in order to identify that evidence
- Cochrane
- PubMed
- Google Scholar
- British Society for Haematology Guidelines 2014
What search terms did you use?
‘pernicious anaemia/ anemia’ and ‘systematic review’
Please describe the parameters of the search (eg time limits, excluded sources, country/language) and the rationale for any limitations
Systematic reviews were excluded if they were:
- more than ten years’ old
- not from the UK
- focused on B12 Deficiency rather than pernicious anaemia
Names of individuals who undertook the evidence checking
Kristina Staley
On what date was the question verification process completed?
14 July 2021
Any other relevant information