Inflammatory Bowel Disease Top 10
- What is the optimal treatment strategy considering efficacy, safety and cost-effectiveness (immunomodulators, biologics, surgery, combinations) in IBD management: selecting the right patient group, right stage of disease, and assessing potential for withdrawal?
- What are the optimal markers/ combinations of markers (clinical, endoscopic, imaging, genetics, other biomarkers) for stratification of patients with regards to a) disease course and b) monitoring disease activity and c) treatment response?
- What role does diet have in the management of mildly active or inactive ulcerative colitis or Crohn’s Disease to achieve normal daily activities and symptom control?
- How can pain be most effectively managed in people with IBD?
- What is an optimal treatment strategy for perianal Crohn’s Disease and what individual factors determine this?
- What is the best treatment for controlling diarrhoea and/or incontinence symptoms in people with IBD, including novel pharmacological and non-pharmacological options? Is high-dose Loperamide safe and effective in the treatment of diarrhoea in IBD?
- What is the optimal dietary therapy (liquid enteral diet and/or reintroduction diet) and duration to achieve mucosal healing in active IBD and/or remission either as a primary or adjunctive treatment? Is there a difference between adults and children?
- What is the association between IBD and fatigue and how should it be managed?
- Does early surgery or later surgery for terminal ileal Crohn’s disease result in better outcomes (quality of life, cost-effectiveness)?
- Does influencing the gut microbiota influence the course of IBD?