Priority 1 from the mitochondrial disease PSP

UNCERTAINTY: Could an understanding of the cellular and molecular processes in mitochondrial disease lead to new treatments? (JLA PSP Priority 1)
Overall ranking 1
JLA question ID 0095/1
Explanatory note Not available 
Evidence

 https://www.ncbi.nlm.nih.gov/pubmed/30535772

Health Research Classification System category
Metabolic and Endocrine
Extra information provided by this PSP
Original uncertainty examples Can we develop new drugs that target fundamental defects across a range of mitochondrial diseases?  ~  What kind if treatments could interfere with the basic mechanisms of cell dysfunction and disease progression over time to delay, stop or reverse tissue dysfunction?
Submitted by Healthcare Professional x 1 
PSP information
PSP unique ID 0095
PSP name Mitochondrial Disease
Total number of uncertainties identified by this PSP. 42  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 19 January 2020