Priority 9 from the Multiple Sclerosis PSP

UNCERTAINTY: Which treatments are effective for pain in people with multiple sclerosis? (JLA PSP Priority 9)
Overall ranking 9
JLA question ID 0016/9
Explanatory note Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects
Evidence

McNicol ED, Midbari A, Eisenberg E. Opioids for neuropathic pain. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD006146. DOI: 10.1002/14651858.CD006146.pub2.

Systematic reviews that need extending or updating

Straube S, Derry S, Moore RA, McQuay HJ. Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD007771. DOI: 10.1002/14651858.CD007771.pub2.

O'Connell NE, Wand BM, Marston L, Spencer S, DeSouza LH. Non-invasive brain stimulation techniques for chronic pain. Cochrane Database of Systematic Reviews 2010, Issue 9. Art. No.: CD008208. DOI: 10.1002/14651858.CD008208.pub2.

Systematic reviews in preparation

Cui Y, Zhishun L, Marchese M, Lee MS, Wang J, Niu J. Acupuncture for multiple sclerosis (Protocol). Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD008210. DOI: 10.1002/14651858.CD008210. Accardi MC, Hallquist MN, Jensen MP, Patterson DR, Lynn SJ, Montgomery GH. Clinical hypnosis for chronic pain in adults (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD010691. DOI: 10.1002/14651858.CD010691.

Ongoing controlled trials

None

Health Research Classification System category Neurological
Extra information provided by this PSP
Original uncertainty examples No examples provided.  This is an indicative uncertainty and several submissions were merged to form this one. 
Submitted by 4 patients ~ 1 carer
Outcomes to be measured Management and or change of multiple sclerosis symptoms; adverse effects or complications; acceptability to patients or carers; time to return to work or normal activity; time in hospital and or needing health or social care services; health related quality of life; and costs.
PSP information
PSP unique ID 0016
PSP name Multiple Sclerosis
Total number of uncertainties identified by this PSP. 82  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop July 2013