Priority 21 from the Kidney Transplant PSP

UNCERTAINTY: How do we prevent the original cause of kidney failure returning (for example glomerulonephritis) following kidney transplant?
Overall ranking Priority questions agreed on but not put in ranked order
JLA question ID 0037/21
Explanatory note Not available for this PSP

Ongoing Randomised Controlled Trial: Burke G. Rituximab to prevent recurrence of proteinuria. NCT01164098 

Health Research Classification System category Renal and Urogenital
Extra information provided by this PSP
Original uncertainty examples

Having suffered prior to transplant from glomerulnephritis,is there any risk that the transplanted kidney could be affected by this condition? Is rituximab and/or plasma exchange effective in the management of recurrent FSGS post-transplant? How can we prevent or treat the recurrence of IgA nephropathy following renal transplantation?


Comparison Drug
Submitted by

Patient x 1 Clinicians x 2

Outcomes to be measured Recurrent FSGS
PSP information
PSP unique ID 0037
PSP name Kidney Transplant
Total number of uncertainties identified by this PSP. 90  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 3 February 2016