Priority 4 from the Mitochondrial Disease PSP

UNCERTAINTY: What biomarkers (biological markers that can be measured e.g. in blood samples) could be used to diagnose mitochondrial disease and to track its progress? (JLA PSP Priority 4)
Overall ranking 4
JLA question ID 0095/4
Explanatory note  Not available

Health Research Classification System category Metabolic and Endocrine
Extra information provided by this PSP
Original uncertainty examples A way to monitor progression. ~ Maybe research could Show what the best blood tests would be needed to spot progression or health changes.  ~ Progression : identification of bio markers of progressive disease  ~ Are there biomarkers (e.g. on retinal imaging) for progression of mitochondrial retinopathy? ~ Pathognomic features or biomerkers for early detection of the disease. ~ Research on diagnostic markers ~ Biomarkers.  ~ studies designed to identify prognostic biomarkers and trial endpoints  
Submitted by  6 x Healthcare Professionals, 2 x Carers
PSP information
PSP unique ID 0095
PSP name Mitochondrial Disease
Total number of uncertainties identified by this PSP. 42  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 19 January 2020