Priority 12 from the Hyperemesis Gravidarum PSP

UNCERTAINTY: Why are some cases of hyperemesis gravidarum unresponsive to all antiemetics and how can we treat such cases? (JLA PSP Priority 12)
Overall ranking 12
JLA question ID 0090/12
Explanatory note Not available for this PSP

Cause of unresponsiveness not addressed in literature. Various novel therapies, enteral/parenteral feeding and termination proposed for unresponsive cases in a small number of papers and the two guidelines. 

Health Research Classification System category Reproductive health and childbirth
Extra information provided by this PSP
Original uncertainty examples Why in some cases is it not possible to control the sickness and vomiting? ~ Why doesn’t medication work (good enough)? ~ Why do different medications or combinations of medications work (or not work) for different patients? ~ Why don’t pills or medications work against the hg effects?
Submitted by Patients x 3
PSP information
PSP unique ID 0090
PSP name Hyperemesis Gravidarum
Total number of uncertainties identified by this PSP. 65  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 9 October 2019