Priority 15 from the Psoriasis PSP

UNCERTAINTY: Could gene therapy help to treat psoriasis? (JLA PSP Priority 15)
Overall ranking 15
JLA question ID 0072/15
Explanatory note Not available for this PSP

Han Evidence that apolipoprotein E (ApoE) polymorphisms are associated with the risk of psoriasis, especially ε2 and ε3 alleles.  Further studies are needed.  

Jia 2013 This meta-analysis evidenced that the TNF-a –238 and –308 promoter polymorphisms may play different roles in conferring susceptibility to psoriasis.  Further functional and well-designed studies should be conducted to confirm these results. 

Lee 2013 This meta-analysis evidenced that the IL-23R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.  Further studies needed. 

Lee 2015 This meta-analysis provided evidence for the vascular endothelial growth factor VEGF +405 C/G polymorphism conferring susceptibility to psoriasis in Asians, with the -460 C/T and -1154 A/G polymorphisms conferring susceptibility to psoriasis in Europeans.  Further investigation of the associations between VEGF polymorphisms and psoriasis susceptibility needed. 

See data sheet for list of evidence considered.

Health Research Classification System category Skin
Extra information provided by this PSP
Original uncertainty examples What gene therapy is being developed to help Psoriasis sufferers?
Submitted by 5 uncertainties were submitted around this question
PSP information
PSP unique ID 0072
PSP name Psoriasis
Total number of uncertainties identified by this PSP. 55  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 17 September 2018