Priority 6 from the Psoriatic Arthritis PSP

UNCERTAINTY: What triggers acute exacerbations and flares of psoriatic arthritis symptoms? (JLA PSP Priority 6)
Overall ranking 6
JLA question ID 0108/6
Explanatory note People who experience acute exacerbations or flares of psoriatic arthritis find it very debilitating. They can make planning everyday activities such as work and social commitments challenging. This question aims to generate evidence to fill the gap concerning what might cause an acute exacerbation or flare of psoriatic arthritis. For example, uncertainties reflecting this question are; why does it seem okay one day and excruciating the next? Why do flare-ups occur? How can I predict if/when a flare will occur?
Evidence

This is an area of uncertainty. No systematic reviews or guidelines identified.
Health Research Classification System category Inflammatory and immune system
Extra information provided by this PSP
Original uncertainty examples Why do flare ups occur? 
Submitted by 18 uncertainties submitted 
PSP information
PSP unique ID 0108
PSP name Psoriatic Arthritis
Total number of uncertainties identified by this PSP. 46  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 12 July 2021