Priority 23 from the Kidney Transplant PSP

UNCERTAINTY: What approaches improve outcomes in adolescent and young adult kidney transplant recipients?
Overall ranking Priority questions agreed on but not put in ranked order
JLA question ID 0037/23
Explanatory note Not available for this PSP
Evidence

Existing Systematic Reviews: Tong, A, Morton, R, Howard, K, Craig, J C. Adolescent experiences following organ transplantation: a systematic review of qualitative studies. Journal of Pediatrics. 2009;155(4):542-9
Existing Randomised Controlled Trials: Levine MH, Reese PP, Wood A, et al. Inferior allograft outcomes in adolescent recipients of renal transplants from ideal deceased donors. Annals of surgery. 2012;255(3):556-564 doi:10.1097/SLA.0b013e3182471665 ~
Hokken-Koelega, A. C., Stijnen, T., de Ridder, M. A., de Muinck Keizer-Schrama, S. M., Wolff, E. D., de Jong, M. C., Donckerwolcke, R. A., Groothoff, J. W., Blum, W. F., Drop, S. L., et al. Growth hormone treatment in growth-retarded adolescents after renal transplant. Lancet. 1994;343(8909):1313-7
Ongoing Randomised Controlled Trials: Kreuzer, M., Prufe, J., Bethe, D., Vogel, C., Grosshennig, A., Armin, K., Oldhafer, M., Dierks, M., Albrecht, U., Muther, S., et al. The TRANSNephro-study examining a new transition model for post-kidney transplant adolescents and an analysis of the present health care: study protocol for a randomized controlled trial. Trials [Electronic Resource]. 2014;15(1):505 Clinicaltrials.gov: ISRCTN22988897 ~
Peers for Promoting Adolescent Transplant Health (Peers4PATH). Children's Hospital of Philadelphia. NCT01450033 ~
Foster, B. J., Pai, A., Zhao, H., Furth, S. The TAKE-IT study: aims, design, and methods. BMC Nephrology. 2014;15(1):139
Health Research Classification System category Renal and Urogenital
Extra information provided by this PSP
Original uncertainty examples

What are the outcomes for young adults who receive kidney transplants as compared to children and older people? What is the rate, and reasons for transplant failure following transition from paediatric to adult healthcare services? How can we improve outcomes in transplantation through adolescence and early adulthood?

 
Comparison Surgery
Submitted by

Clinicians x 3
Outcomes to be measured Patient and graft survival, graft function, adverse events
PSP information
PSP unique ID 0037
PSP name Kidney Transplant
Total number of uncertainties identified by this PSP. 90  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 3 February 2016