Priority 4 from the Obstructive Sleep Apnea (Saskatchewan,Canada) PSP

UNCERTAINTY: What are important considerations when treating a patient with obstructive sleep apnea (OSA) who has other chronic health conditions? (JLA PSP Priority 4)
Overall ranking 4
JLA question ID 0118/4
Explanatory note Obstructive Sleep Apnea is often associated with metabolic (e.g., diabetes),respiratory (e.g. Chronic Obstructive Pulmonary Disease) and cardiovascular (e.g., high blood pressure) diseases. Patients with Obstructive Sleep Apnea and other conditions may be taking multiple medications, which can sometimes result in adverse reactions. Effective management of OSA and other conditions at the same time can be difficult for both health care providers and for patients. Treatiing each condition in isolation can lead to less effective management and complicated interactions for the patient with the healthcare system. 
Evidence

Singh G, Agarwal A, Zhang W, Kuo YF, Sultana R, Sharma G. Impact of PAP therapy on hospitalization rates in Medicare beneficiaries with COPD and coexisting OSA. Sleep Breath. 2019 Mar;23(1):193-200. doi:10.1007/s11325-018-1680-0. Epub 2018 Jun 22. PMID: 29931497; PMCID: PMC6309578. 
Health Research Classification System category Respiratory
Extra information provided by this PSP
Original uncertainty examples Will it really treat other things if sleep apnea is controlled with machine?; Do medications (syntroid & blood thinner) affect my sleep apnea. (also in thyroid theme)Do valve replacements have an affect as well? 
Submitted by Patients x 8,  clinicians x 2, family members x 3 
PSP information
PSP unique ID 0118
PSP name Obstructive Sleep Apnea PSP
Total number of uncertainties identified by this PSP. 39  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 28 January 2021