Priority 6 from the Blood Pressure in Pregnancy PSP

UNCERTAINTY: How can pregnancy hypertension (including pre-eclampsia) be prevented in a subsequent pregnancy? (JLA PSP Priority 6)
Overall ranking 6
JLA question ID 0099/6
Explanatory note Not available for this PSP
Evidence

Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.Hofmeyr GJ, Lawrie TA, Atallah ÁN, Torloni MR.Cochrane Database Syst Rev. 2018 Oct 1;10:CD001059. doi: 10.1002/14651858.CD001059.pub5.PMID:30277579

Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials.Kalafat E, Sukur YE, Abdi A, Thilaganathan B, Khalil A.Ultrasound Obstet Gynecol. 2018 Dec;52(6):706-714. doi: 10.1002/uog.19084. Epub 2018 Nov 1.PMID:29749110

Zinc supplementation for improving pregnancy and infant outcome.Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K, Miyazaki C, Bhutta ZA.Cochrane Database Syst Rev. 2015 Feb 2;(2):CD000230. doi: 10.1002/14651858.CD000230.pub5. Review.PMID:25927101

Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: a systematic review.Gui S, Jia J, Niu X, Bai Y, Zou H, Deng J, Zhou R.J Renin Angiotensin Aldosterone Syst. 2014 Mar;15(1):88-96. doi: 10.1177/1470320313475910. Epub 2013 Feb 22. Review.PMID:23435582

Antioxidants for preventing pre-eclampsia.Rumbold A, Duley L, Crowther CA, Haslam RR.Cochrane Database Syst Rev. 2008 Jan 23;(1):CD004227. doi: 10.1002/14651858.CD004227.pub3. Review.PMID:18254042

Health Research Classification System category  Reproductive health and childbirth
Extra information provided by this PSP
Original uncertainty examples What can I do to prevent preeclampsia? (I was a healthy first time mom with good BPs until around week 36, so it wasn´t prior history for me.) ~ How can it be prevented What are the best ways to help keep blood pressure down in pregnancy Is high blood pressure in pregnancy ever preventable and how? ~ Will it ever be preventable Is there anything that can prevent / reduce risk  high BP What can be done to prevent high blood pressure in pregnancy? ~ Are there any risks involved with preventative measures (for baby and mother) ~ Could I have done anything to prevent HELLP syndrome? 
Submitted by 11 women, 1 who knew a person/relative/friend with pregnancy hypertension, 1 researcher, 1 other 
PSP information
PSP unique ID 0099
PSP name Blood Pressure in Pregnancy
Total number of uncertainties identified by this PSP.

50 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)

Date of priority setting workshop 20 June 2019