Chapter 2: James Lind Alliance Methods and Principles
Why involve patients and clinicians in setting research priorities?
People have suffered and died unnecessarily because uncertainties about the effects of treatments have not been addressed in research , ,  . Patients and the public have a right to expect that research funders, researchers and health professionals will identify uncertainties about whether treatments or other interventions are doing more harm than good or whether one treatment is better than another, and should expect them to organise the research needed to reduce the most important of these uncertainties.
Historically, research on the effects of treatments has overlooked the shared priorities of patients, carers and clinicians. The pharmaceutical and medical technology industries and academia play essential roles in developing and testing new treatments, but their priorities are not necessarily the same as those of patients and clinicians. Many areas of potentially important research are therefore neglected, and there can be a mismatch between the research being carried out and the research evidence needed by patients and clinicians every day ,. This also leads to an avoidable waste of precious research funds . The JLA method was developed to address this.