Priority 8 from the Neurodevelopmental Disorders Canada PSP

UNCERTAINTY: Which are the most effective pharmacological and non-pharmacological treatments for aggressive and self-injurious behaviour in individuals with neurodevelopmental disorders?  (JLA PSP Priority 8)
Overall ranking 8
JLA question ID 0056/8
Explanatory note This question is aimed at identifying which treatments are best to improve aggressive or self-injurious behaviour. There is interest in knowing which medication-based treatments are best and which non-medication options (e.g. cognitive behavioural therapy) work best.
Evidence Systematic review: Ali A,Hall I, Blickwedel J,Hassiotis A. Behavioural and cognitive-behavioural interventions for outwardly-directed aggressive behaviour in people with intellectual disabilities. Cochrane Database of Systematic Reviews 2015, Issue 4. Art
Health Research Classification System category Mental Health
Extra information provided by this PSP
Original uncertainty examples Are there ways to prevent aggression from developing in individuals with neurodevelopmental disorders (specifically in the autism population)? ~ How can aggressive and self-harm symptoms be mitigated? ~ What are the most effective non-medication  treatments for reducing aggression in children with ADHD?
Submitted by Mostly family members/carers
PSP information
PSP unique ID 0056
PSP name Neurodevelopmental Disorders (Canada)
Total number of uncertainties identified by this PSP. 63  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 28 September 2017