Other Priority 6 from the Early Hip and Knee Osteoarthritis PSP

UNCERTAINTY: What factors and patterns of disease are responsible for progression of OA?  (JLA PSP Other Priority 6)
Overall ranking amongst other questions 6
JLA question ID 0041/26
Extra explanatory note Some knowledge but needs to be better, need to personalise approaches. Need development of predictive tool
Type of research; Longitudinal, Retrospective, Cohort, Epidemiological
EP databases, Big data, Developing a predictive tool – risk factors (e.g. of family history)
Population; large!
Outcomes; PROMS/PIOMS, X-Ray/MRI
Evidence None identified
Health Research Classification System category Musculoskeletal
Extra information provided by this PSP
Original uncertainty examples Has a cause been identified yet?  ~  Which phenotypes are most likely to lead to joint failure?  ~  What aggs and what eases symptoms?  ~  Why is it worse on some days than other?
Submitted by 7 patient/carers, 6 clinicians and 1 carer/clinician
PSP information
PSP unique ID 0041
PSP name Early Hip and Knee Osteoarthritis
Total number of uncertainties identified by this PSP. 52  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 26 February 2016