Other Priority 1 from the Early Hip and Knee Osteoarthritis PSP

UNCERTAINTY: Can early OA be slowed down, reversed or cured? (JLA PSP Other Priority 1)
Overall ranking amongst other questions 1
JLA question ID 0041/21
Extra explanatory note Uncertainties about effect of existing or new treatments somewhat open to interpretation regarding potential medical, surgical contexts for use.
Type of research; longer term and/or clinical trial (self management adding on to existing treatment) e.g. 1. drug trial
2. surgical e.g. alignment surgery 3. non-pharmacological e.g. weight loss
Intervention; Surgical – corrective alignment surgery, Drugs / injection, Brace/ orthotics/ non-pharma e.g. acupuncture, Weight loss
Population; early disease: all patients, but may be younger, people who are at risk, early trauma/ sport, overweight, family risk, congenital
Outcomes; Validated knee measure or hip e.g. KOOS (Knee Injury and Osteoarthritis Outcome Score), OKS-APQ (Oxford Knee Score - Activity & Participation Questionnaire), Occupational / activity EQ-5D index and VAS PROMS measures (Index = health-related quality of life - mobility, self-care, usual activities, pain/discomfort and anxiety/depression
VAS = a self-rating of health-related quality of life, Pain, Imaging (MRI)/ X-Ray – but neither are definitive
Evidence

None identified
Health Research Classification System category Musculoskeletal
Extra information provided by this PSP
Original uncertainty examples

Are we in sight of a cure?  ~  Can the disease & damage be reversed at all?  ~  Is it curable? 
Submitted by 3 patient/carers and 1 clinician
PSP information
PSP unique ID 0041
PSP name Early Hip and Knee Osteoarthritis
Total number of uncertainties identified by this PSP. 52  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 26 February 2016