Non Surgical Priority 8 from the Early Hip and Knee Osteoarthritis PSP


UNCERTAINTY: What new drug treatments are effective in treating people with early OA? (JLA PSP Non Surgical Priority 8)
Overall ranking amongst non surgical questions 8
JLA question ID 0041/18
Extra explanatory note Changed the focus of this question on new drug treatments as existing ones not very effective and not suitable for everyone (e.g. NSAIDs). Also remove joint injections as specific question about these (no 11).
Intervention; Topical and oral drugs new (or repurposed), use in flares, activity related pain and chronic and enduring pain
Type of research; this would be good for a systematic review to begin with
Population;
Outcomes; benefits (pain reduction) and side and adverse effects (especially cardiovascular and peptic ulcer related)
Evidence

None identified
Health Research Classification System category Musculoskeletal
Extra information provided by this PSP
Original uncertainty examples Medication that helps to ease symptoms?  ~  Are any of the recommended treatments more effective if given in defined early stages?  ~  Are there any cartilage supplements that prevent/slow down cartilage degeneration?  ~  Should I be having steroid injections in my knees to settle synovitis?
Submitted by 5 patient/carers, 14 clinicians and 6 H&K PSP (3 clinicians and 3 patient/carer) focus groups.
PSP information
PSP unique ID 0041
PSP name Early Hip and Knee Osteoarthritis
Total number of uncertainties identified by this PSP. 52  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 26 February 2016