Priority 7 Stroke Prevention, Diagnosis, Pre-hospital and Hospital Care
|UNCERTAINTY: What are the processes that cause delayed changes in brain function (neurological deficit) after subarachnoid haemorrhage caused by an aneurysm? (JLA PSP Priority 7)|
|JLA question ID||0106/7a|
Subarachnoid haemorrhages (SAH) are often caused by a burst blood vessel in the brain (a ruptured brain aneurysm) [Ref. 7].
Aneurysmal SAH affects six to nine people per 100,000 per year, has a 35% mortality, and leaves many with lasting disabilities, often related to cognitive dysfunction [Ref. 8]. Delayed ischemic neurologic deficit (DIND) is the main preventable cause of poor outcomes in aneurysmal subarachnoid haemorrhage (SAH) patients [Ref. 9]. However, evidence is needed to understand the processes to develop treatments to prevent DIND.
Ref 7: https://www.nhs.uk/conditions/subarachnoid-haemorrhage/
No evidence identified
|Health Research Classification System category||Stroke|
|Extra information provided by this PSP|
|Original uncertainty examples||What are the mechanisms underpinning onset of delayed neurological deficit after aneurysmal subarachnoid haemorrhage?|
|Submitted by||Health/Social Care professional x 1|
|PSP unique ID||0106|
|PSP name||Stroke prevention, diagnosis, pre-hospital and hospital care|
|Total number of uncertainties identified by this PSP.||93 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)|
|Date of priority setting workshop||30th April 2021|