A multi-centre randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury

Addressing priority 1: NIHR research in progress

Depression is very common following a traumatic brain injury, also called a head injury. Around 50% of people with a head injury will have some form of depression over the next 10 years. This is almost 10 times more common than the general public. The patient and public involvement group for this project agreed that trying to prevent depression occurring is very important. The idea that antidepressants given early could stop depression in the first place after a traumatic brain injury was appealing. They said they would want to be given everything for the best chance of recovery. In this study, the team wants to find out if a commonly used antidepressant called sertraline, is better at preventing depression than a placebo (also called a dummy or 'fake' pill). They also want to study if sertraline improves quality of life, improves other symptoms like headaches, irritability, memory loss, and reduces stress for carers. 

The clinical and cost-effectiveness of exercise intervention for depression in adolescents: a phased multi-site randomised controlled trial

Addressing priority 18: NIHR research in progress.

Depression in adolescents is a serious problem that can lead to poor mental health and stigma throughout a person's life. Depression is reported in around 20% of young people by the time they are 18 years of age. Over half continue to be depressed into adulthood, with many attempting suicide. Problems include difficulties at home and school, maintaining friendships and taking part in social activities, including exercise. Young people with depression often delay seeking psychological support. Antidepressants can help some, but they have negative side effects. Research shows that adults with depression benefit from exercise, but it is not known whether exercise is helpful for young people who are depressed. The aim of this research is to find out whether exercise is an effective treatment for young people with depression and whether it is good value for money for the NHS.