Priority 2 from the Electronic Cigarettes PSP

UNCERTAINTY: What effect do the ingredients, chemicals and flavourings have on health, and how does this differ from cigarettes? (JLA PSP Priority 1)
Overall ranking 2
JLA question ID 0087/2
Explanatory note  Not available for this PSP
Evidence

Zulkifli, Aziemah, et al. "Electronic cigarettes: a systematic review of available studies on health risk assessment." Reviews on environmental health 33.1 (2018): 43-52.  looks at 4 ingredients (nicotine, PG, glycerol, 1,2-propanediol). Only 4 studies. Inconsistent evidence.  Would be useful to have human studies here rather than in vitro or mice studies
Health Research Classification System category  Generic health relevance
Extra information provided by this PSP
Original uncertainty examples How the ingredients in eliquid may or may not affect health. This must include various additives such as sweeteners etc. ~ What ingredients in common e-juices are carcinogenic and what are the levels of carcinogens relative to cigarettes? ~ Short term health effects ~ What are the short-term harms of vaping compared to tobacco smoking
Submitted by  13 x Healthcare professionals, 124 x Patients
PSP information
PSP unique ID 0087
PSP name Electronic Cigarettes
Total number of uncertainties identified by this PSP. 52 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 20 September 2019