Priority 15 from the Electronic Cigarettes PSP

UNCERTAINTY: What are the short term effects of vaping? Compared to smoking, ex-smokers, never-smokers and NRT use? (JLA PSP Priority 15)
Overall ranking 15
JLA question ID 0087/15
Explanatory note Not available for this PSP

Although PHE do state that the evidence suggests e-cigarettes are 95% safer than smoking, with the recent deaths in America from vaping more research and evidence would give weight to this position statement, particularly if we can have more research on a broader range of biomarkers. 

Liu, Xing, et al. "Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article)." Medicine 97.19 (2018). Looks at adverse events in smokers. Doesn't compare to smoking, ex-smoking, non-smokers. Would be good to have a fresh look at this. There are a few well conducted studies e.g.: Ann Intern Med. 2017 Mar 21;166(6):390-400. doi: 10.7326/M16-1107. Epub 2017 Feb 7.
Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users: A Cross-sectional Study.

Health Research Classification System category  Generic health relevance
Extra information provided by this PSP
Original uncertainty examples

 Short term health effects? ~ What are the short-term harms of vaping compared to tobacco smoking

Submitted by  34 x Healthcare Professionals, 124 x Patients
PSP information
PSP unique ID 0087
PSP name Electronic Cigarettes
Total number of uncertainties identified by this PSP. 52 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 20 September 2019