Priority 1 from the Cavernoma PSP

UNCERTAINTY: Does treatment (with neurosurgery or sterotactic radiosurgery) or no treatment improve outcome for people diagnosed with brain or spine cavernoma? (JLA PSP Priority 1)
Overall ranking 1
JLA question ID 0035/1
Explanatory note Not available for this PSP

Wang X, Mei G, Liu X, Dai J, Pan L, Wang E. The role of stereotactic radiosurgery in cavernous sinus hemangiomas: a systematic review and meta‐analysis. J Neuro‐Oncol. 2012;107(2):239‐45.  doi: 10.1007/s11060-011-0753-8. Epub 2011 Nov 16.                                                                                     

Lu XY, Sun H, Xu JG, Li QY. Stereotactic radiosurgery of brainstem cavernous malformations: a systematic review and meta‐analysis. J Neurosurg. 2014;120(4):982‐7. doi: 10.3171/2013.12.JNS13990. Epub 2014 Feb 7.                   

Badhiwala J.H. Farrokhyar F. Alhazzani W. Yarascavitch B. Ed Aref M. Algird A, et al. Surgical outcomes and natural history of intramedullary spinal cord cavernous malformations: a single-center series and meta-analysis of individual patient data. Journal of Neurosurgery: Spine. 2014;21 (4):662-76. doi: 10.3171/2014.6.SPINE13949. Epub 2014 Jul 25. 

Poorthuis M. Samarasekera N. Kontoh K. Stuart I. Cope B. Kitchen N. Al-Shahi Salman R. Comparative studies of the diagnosis and treatment of cerebral cavernous malformations in adults: Systematic review. Acta Neurochirurg. 2013;155 (4):643-9. doi: 10.1007/s00701-013-1621-4. Epub 2013 Jan 31.                                                                                         

Poorthuis MH, Klijn CJ, Algra A, Rinkel GJ, Al‐Shahi Salman R. Treatment of cerebral cavernous malformations: a systematic review and meta‐regression analysis. J Neurol Neurosurg Psychiatr. 2014; 85(12):1319-23. doi: 10.1136/jnnp-2013-307349. Epub 2014 Mar 25.   

Health Research Classification System category Neurological
Extra information provided by this PSP
Original uncertainty examples Not available
Comparison Surgery; Service delivery
Submitted by 120 patients. 28 clinicians.
Outcomes to be measured Prognosis: change in symptoms, or change in management of symptoms; adverse effects or complications; patient satisfaction; health related quality of life; service related issues; and health related cost
PSP information
PSP unique ID 0035
PSP name Cavernoma
Total number of uncertainties identified by this PSP. 54  
Date of priority setting workshop 23 September 2015