Priority 22 from the Degenerative Cervical Myelopathy PSP
|UNCERTAINTY: Can CSF or serum biomarkers be identified to support early diagnosis of DCM, and/or predict treatment outcomes? (JLA PSP Priority 22)
|JLA question ID
|There is limited evidence to suggest that routinely-collected clinical and imaging factors can predict the onset of DCM and detect early neurological deterioration. Recent studies have attempted to use various imaging biomarkers to quantify axonal/myeln injury, cellular inflammation, neuronal loss and white matter changes. These approaches may have the potential to improve diagnosis, monitor progression and predict treatment outcomes. A pilot study by Jenis et al (2011) identified important differences in the cerebrospinal fluid between normal controls and patents with DCM. Proteonomic analysis of the cerebrospinal fluid revealed that patients with DCM have decreased human brain-derived neurotropic factor and pigment epithelium derived factor and elevated apolipoprotein A-1 and vascular endothelial growth factor.
No systematic reviews, scoping reviews or guidelines identified
|Health Research Classification System category
|Extra information provided by this PSP
|Original uncertainty examples
Bio markers for early diagnosis? ~ Could we get any clues about DCM from analysing the CSF? ~ Is it possible to find a serum biomarker that predict the prognosis of DCM? ~ What is the role of biomarkers in the diagnosis and follow-up of patients with DCM?
|Spinal Surgeons x 11, Other healthcare professionals x 1, People with DCM and their supporters x 1
|PSP unique ID
|Degenerative Cervical Myelopathy
|Total number of uncertainties identified by this PSP.
|76 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
|Date of priority setting workshop
|20 November 2019