Priority from the Teenage and Young Adult Cancer PSP

UNCERTAINTY: What key factors (both cancer and individual) determine whether a treatment plan for children or adults will give better outcomes?
Overall ranking This was one of the 20 questions at the workshop that fell outside of the Top 10. These were not ranked in any order of priority
JLA question ID 0060/14
Explanatory note We have increasing knowledge about the role of genetics, personal characteristics, and tumour biology. We are beginning to understand more about therapies in relation to this, but there is much we still do not know

None identified

Health Research Classification System category Cancer
Extra information provided by this PSP
Original uncertainty examples What are the clinically relevent differences in drug metabolism in TYA from children which can guide therapy choices? ~ My son was 14 and the question during treatment was whether to use child or adult doses as there was not much data on teensgers. Would like to see more research on this area ~ What is the best way of integrating the instances where the standard paediatric and adult management of the same cancer (e.g. Hodgkin lymphoma) differ? i.e. What is best for the TYA patient in this circumstance? ~ How do we ensure that treatment is suitable for the disease process/biology in a specific cancer in a TYA patient in order that they receive optimum treatment?
Submitted by 6 x health professionals ~ 1 x parent/carers 
PSP information
PSP unique ID 0060
PSP name Teenage and Young Adult Cancer
Total number of uncertainties identified by this PSP. 185  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 19 January 2018